Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468477083> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2468477083 endingPage "4" @default.
- W2468477083 startingPage "171" @default.
- W2468477083 abstract "In this study, 50 patients were randomly assigned to treatment with 5-fluorouracil (FUra) or FUra plus high-dose continuous-infusion folinic acid. Five of 27 evaluable patients in the FUra group versus 10 of 21 patients in the FUra plus folinic acid arm of the study had objective partial remissions, P = 0.02. Time to progression was 3.9 months for FUra and 8.0 months for FUra and folinic acid, P = 0.006; however, median survivals (11.9 versus 14.5 months) were not different in this crossover study. Toxicity in both treatment arms was mild, although patients receiving FUra plus folinic acid experienced significantly more stomatitis than patients treated with FUra alone. This study suggests that high-dose, continuous-infusion folinic acid, which produces a steady-state level of biologically active folates of 10 microM, significantly increases the therapeutic activity of FUra." @default.
- W2468477083 created "2016-07-22" @default.
- W2468477083 creator A5004437433 @default.
- W2468477083 creator A5010093399 @default.
- W2468477083 creator A5018527792 @default.
- W2468477083 creator A5030495245 @default.
- W2468477083 creator A5031039242 @default.
- W2468477083 creator A5032317761 @default.
- W2468477083 creator A5053680914 @default.
- W2468477083 creator A5079414611 @default.
- W2468477083 creator A5084347950 @default.
- W2468477083 creator A5085394609 @default.
- W2468477083 date "1987-01-01" @default.
- W2468477083 modified "2023-09-23" @default.
- W2468477083 title "Preliminary analysis of a randomized comparison of 5-fluorouracil versus 5-fluorouracil and high-dose continuous-infusion folinic acid in disseminated colorectal cancer." @default.
- W2468477083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3501538" @default.
- W2468477083 hasPublicationYear "1987" @default.
- W2468477083 type Work @default.
- W2468477083 sameAs 2468477083 @default.
- W2468477083 citedByCount "6" @default.
- W2468477083 crossrefType "journal-article" @default.
- W2468477083 hasAuthorship W2468477083A5004437433 @default.
- W2468477083 hasAuthorship W2468477083A5010093399 @default.
- W2468477083 hasAuthorship W2468477083A5018527792 @default.
- W2468477083 hasAuthorship W2468477083A5030495245 @default.
- W2468477083 hasAuthorship W2468477083A5031039242 @default.
- W2468477083 hasAuthorship W2468477083A5032317761 @default.
- W2468477083 hasAuthorship W2468477083A5053680914 @default.
- W2468477083 hasAuthorship W2468477083A5079414611 @default.
- W2468477083 hasAuthorship W2468477083A5084347950 @default.
- W2468477083 hasAuthorship W2468477083A5085394609 @default.
- W2468477083 hasConcept C121608353 @default.
- W2468477083 hasConcept C126322002 @default.
- W2468477083 hasConcept C2776694085 @default.
- W2468477083 hasConcept C2778397455 @default.
- W2468477083 hasConcept C2779804826 @default.
- W2468477083 hasConcept C2780456651 @default.
- W2468477083 hasConcept C29730261 @default.
- W2468477083 hasConcept C526805850 @default.
- W2468477083 hasConcept C71924100 @default.
- W2468477083 hasConcept C90924648 @default.
- W2468477083 hasConcept C98274493 @default.
- W2468477083 hasConceptScore W2468477083C121608353 @default.
- W2468477083 hasConceptScore W2468477083C126322002 @default.
- W2468477083 hasConceptScore W2468477083C2776694085 @default.
- W2468477083 hasConceptScore W2468477083C2778397455 @default.
- W2468477083 hasConceptScore W2468477083C2779804826 @default.
- W2468477083 hasConceptScore W2468477083C2780456651 @default.
- W2468477083 hasConceptScore W2468477083C29730261 @default.
- W2468477083 hasConceptScore W2468477083C526805850 @default.
- W2468477083 hasConceptScore W2468477083C71924100 @default.
- W2468477083 hasConceptScore W2468477083C90924648 @default.
- W2468477083 hasConceptScore W2468477083C98274493 @default.
- W2468477083 hasIssue "5" @default.
- W2468477083 hasLocation W24684770831 @default.
- W2468477083 hasOpenAccess W2468477083 @default.
- W2468477083 hasPrimaryLocation W24684770831 @default.
- W2468477083 hasRelatedWork W1980941352 @default.
- W2468477083 hasRelatedWork W1981794048 @default.
- W2468477083 hasRelatedWork W1993173997 @default.
- W2468477083 hasRelatedWork W2010991676 @default.
- W2468477083 hasRelatedWork W2013155989 @default.
- W2468477083 hasRelatedWork W2026026870 @default.
- W2468477083 hasRelatedWork W2031477213 @default.
- W2468477083 hasRelatedWork W2066199524 @default.
- W2468477083 hasRelatedWork W2072252734 @default.
- W2468477083 hasRelatedWork W2015191990 @default.
- W2468477083 isParatext "false" @default.
- W2468477083 isRetracted "false" @default.
- W2468477083 magId "2468477083" @default.
- W2468477083 workType "article" @default.