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- W2468563130 abstract "Here we report the construction and use of a full-length env gene-cassetting system, C2, based on the HIV-1 infectious molecular clone NL43. C2 produces virus with the same phenotype as NL43 but with 2-fold lower growth kinetics. The latter probably relates to alteration in the vpu and/or nef genes. C2-env chimeras of macrophage-tropic and T cell-tropic laboratory strains and primary HIV-1 isolates retain the glycoprotein-determined phenotypes of their parent viruses. The cassette will assist studies of HIV-1 pathogenesis." @default.
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- W2468563130 date "2001-11-01" @default.
- W2468563130 modified "2023-09-25" @default.
- W2468563130 title "<i>Short Communication:</i>Maintenance of Glycoprotein-Determined Phenotype in an HIV Type 1 (pNL43)<i>env</i>Gene-Cassetting System" @default.
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- W2468563130 doi "https://doi.org/10.1089/08892220152644205" @default.
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