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- W2468565531 abstract "Pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (PECPDQ) having potential coordinating sites was synthesized and 2D HETCOR (1H-13C) NMR studies were successfully used to demonstrate the formation of 1,2-dihydroquinzolinone rather than Schiff base in the reaction between 2-acetylpyridine-2-aminobenzoylhydrazone and benzaldehyde. The transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) of PECPDQ were prepared, characterized and subjected for antimicrobial activity along with the pro-ligand. The anti-microbial activity results show that the complexes exhibit higher activity compared to ligand due to their increased lipophilic character. Mn(II), Co(II) and Cd(II) complexes were found to be most potent inhibitors against bacterial strain and the activity is even more than the standard anti-bacterial drug Norfloxacin. Similarly, the anti-fungal activity of ligand has enhanced on complexation but not more than standard anti-fungal drug ie., Gresiofulvin used." @default.
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- W2468565531 date "2010-01-01" @default.
- W2468565531 modified "2023-09-24" @default.
- W2468565531 title "2D HETCOR studies of 1,2-dihydroquinazolinone derivative: Synthesis characterization and anti-microbial study of its transition metal complexes" @default.
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