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• W2468617660 abstract "Surfactant protein A (SP-A) influences the function of alveolar macrophages in vitro. In this study the characteristics of the binding of 125I-labeled SP-A to rat alveolar macrophages has been investigated. The binding of SP-A to alveolar macrophages at 4 degrees C was saturable with half-maximal binding at a SP-A concentration of 4 micrograms/ml. Bound SP-A was rapidly displaced by an excess of unlabeled SP-A. The binding of labeled SP-A to the alveolar macrophages was blocked in a dose-dependent fashion by unlabeled SP-A, the collagen-like protein C1q and type V collagen but not by bovine serum albumin. These results suggest that a component of the interaction between SP-A and alveolar macrophages is mediated through the collagen-like domain of SP-A and that the characteristics of this interaction are consistent with there being a specific receptor for SP-A on the surface of alveolar macrophages." @default.
• W2468617660 created "2016-07-22" @default.
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• W2468617660 date "1992-04-01" @default.
• W2468617660 modified "2023-10-16" @default.
• W2468617660 title "Specific binding of surfactant apoprotein SP-A to rat alveolar macrophages" @default.
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• W2468617660 doi "https://doi.org/10.1152/ajplung.1992.262.4.l412" @default.
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