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- W2468638265 abstract "Anemia often occurs in patients with advanced chronic kidney disease (CKD) as a result of erythropoietin deficiency and thus is responsive to erythropoiesis-stimulating agents (ESAs). Usually, anemia in patients with stages 3 and 4 CKD is moderate (arbitrarily defined as hemoglobin [Hb] level 10 g/dL, but lower than normal) and marked by a slow decline in Hb level 1 ; it is asymptomatic and its treatment rarely requires transfusions. However, in dialysis patients, anemia typically is more severe, Hb level may decrease rapidly, quality of life often is impaired, and transfusions frequently are required. 2 Four recombinant human erythropoietins (epoetin alfa, epoetin beta, darbepoetin alfa, and methoxy polyethylene glycol‐epoetin beta) have been used to treat anemia. Recently, a new approach using the peptide-based erythropoietic agent peginesatide, a dimeric pegylated peptide, was evaluated in 2 randomized controlled trials published in NEJM in early 2013, EMERALD and PEARL. 3,4" @default.
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- W2468638265 date "2013-01-01" @default.
- W2468638265 modified "2023-09-24" @default.
- W2468638265 title "On Peginesatide and Anemia Treatment in CKD" @default.
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