FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468763224> ?p ?o ?g. }

• W2468763224 abstract "Eosinophilic esophagitis (EoE) has been defined as a ‘chronic, immune/antigen-mediated, esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation'. A peak value of ≥15 eosinophils/high power field has been defined as histologic diagnostic cutoff. Other conditions associated with esophageal eosinophilia, such as gastro-esophageal reflux disease, PPI-responsive esophageal eosinophilia or Crohn's disease, need to be ruled out before EoE can be diagnosed. Males are affected more frequently than females and most of the patients have concomitant allergies. Currently, the EoE prevalence is about 1 of 2,000 inhabitants in Westernized countries. The first EoE patients were described only 2 decades ago. Despite this short period, considerable progress has been made regarding the understanding of the pathophysiology, natural history, assessment of disease activity and with respect to evaluating different therapeutic options. Untreated EoE can lead to esophageal remodeling with reduced compliance and stricture formation, which represents the main risk factor for food bolus impactions. The therapeutic options can be summarized with the 3 D's, which stand for drugs, diets and dilation. Of note, as of yet, there is no EoE-specific drug that has been approved by regulatory authorities. This is, among other reasons, related to the lack of validated outcome measurement instruments until recently. Swallowed topical steroids such as budesonide or fluticasone represent the standard of care for treating symptomatic pediatric and adult EoE patients with inflammatory activity. Several trials have already evaluated different biologic therapies, such as anti-interleukin-5 or anti-IgE. Further studies are on the way. As a non-pharmacologic alternative, different dietary regimens exist. Dilation can offer long-lasting symptomatic response in case of stricturing EoE but does not have any impact on the underlying inflammation. This review highlights the latest insights regarding pathophysiology and its impact regarding current and future therapeutic strategies." @default.
• W2468763224 created "2016-07-22" @default.
• W2468763224 creator A5005119542 @default.
• W2468763224 creator A5010594551 @default.
• W2468763224 creator A5014026215 @default.
• W2468763224 date "2016-01-01" @default.
• W2468763224 modified "2023-09-23" @default.
• W2468763224 title "Eosinophilic Esophagitis: Impact of Latest Insights Into Pathophysiology on Therapeutic Strategies" @default.
• W2468763224 cites W1592669157 @default.
• W2468763224 cites W1928006163 @default.
• W2468763224 cites W1929913367 @default.
• W2468763224 cites W1967712610 @default.
• W2468763224 cites W1970395867 @default.
• W2468763224 cites W1972578247 @default.
• W2468763224 cites W1974997545 @default.
• W2468763224 cites W1975480455 @default.
• W2468763224 cites W1981091383 @default.
• W2468763224 cites W1983473880 @default.
• W2468763224 cites W1984895205 @default.
• W2468763224 cites W1990729942 @default.
• W2468763224 cites W1995481725 @default.
• W2468763224 cites W1996868215 @default.
• W2468763224 cites W2003791177 @default.
• W2468763224 cites W2009522761 @default.
• W2468763224 cites W2019152596 @default.
• W2468763224 cites W2027881380 @default.
• W2468763224 cites W2034453465 @default.
• W2468763224 cites W2036399312 @default.
• W2468763224 cites W2040099308 @default.
• W2468763224 cites W2044562596 @default.
• W2468763224 cites W2047813376 @default.
• W2468763224 cites W2050056753 @default.
• W2468763224 cites W2054917877 @default.
• W2468763224 cites W2055185627 @default.
• W2468763224 cites W2060423369 @default.
• W2468763224 cites W2061161839 @default.
• W2468763224 cites W2067628108 @default.
• W2468763224 cites W2068429932 @default.
• W2468763224 cites W2068699438 @default.
• W2468763224 cites W2077290680 @default.
• W2468763224 cites W2078475980 @default.
• W2468763224 cites W2078900266 @default.
• W2468763224 cites W2082299692 @default.
• W2468763224 cites W2083403524 @default.
• W2468763224 cites W2085080095 @default.
• W2468763224 cites W2086384139 @default.
• W2468763224 cites W2087770516 @default.
• W2468763224 cites W2091168975 @default.
• W2468763224 cites W2092078565 @default.
• W2468763224 cites W2094798162 @default.
• W2468763224 cites W2098392838 @default.
• W2468763224 cites W2104791884 @default.
• W2468763224 cites W2105545427 @default.
• W2468763224 cites W2109712208 @default.
• W2468763224 cites W2116404775 @default.
• W2468763224 cites W2124164203 @default.
• W2468763224 cites W2127288475 @default.
• W2468763224 cites W2133283119 @default.
• W2468763224 cites W2136248567 @default.
• W2468763224 cites W2136380874 @default.
• W2468763224 cites W2139142626 @default.
• W2468763224 cites W2140974346 @default.
• W2468763224 cites W2145797044 @default.
• W2468763224 cites W2153162249 @default.
• W2468763224 cites W2162528206 @default.
• W2468763224 cites W2317226961 @default.
• W2468763224 cites W2421238964 @default.
• W2468763224 doi "https://doi.org/10.1159/000445201" @default.
• W2468763224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27333298" @default.
• W2468763224 hasPublicationYear "2016" @default.
• W2468763224 type Work @default.
• W2468763224 sameAs 2468763224 @default.
• W2468763224 citedByCount "6" @default.
• W2468763224 countsByYear W24687632242017 @default.
• W2468763224 countsByYear W24687632242018 @default.
• W2468763224 countsByYear W24687632242019 @default.
• W2468763224 countsByYear W24687632242020 @default.
• W2468763224 crossrefType "journal-article" @default.
• W2468763224 hasAuthorship W2468763224A5005119542 @default.
• W2468763224 hasAuthorship W2468763224A5010594551 @default.
• W2468763224 hasAuthorship W2468763224A5014026215 @default.
• W2468763224 hasConcept C126322002 @default.
• W2468763224 hasConcept C177713679 @default.
• W2468763224 hasConcept C2776042228 @default.
• W2468763224 hasConcept C2776136866 @default.
• W2468763224 hasConcept C2777129736 @default.
• W2468763224 hasConcept C2779134260 @default.
• W2468763224 hasConcept C2779920096 @default.
• W2468763224 hasConcept C2781065132 @default.
• W2468763224 hasConcept C43270747 @default.
• W2468763224 hasConcept C71924100 @default.
• W2468763224 hasConcept C90924648 @default.
• W2468763224 hasConceptScore W2468763224C126322002 @default.
• W2468763224 hasConceptScore W2468763224C177713679 @default.
• W2468763224 hasConceptScore W2468763224C2776042228 @default.
• W2468763224 hasConceptScore W2468763224C2776136866 @default.
• W2468763224 hasConceptScore W2468763224C2777129736 @default.
• W2468763224 hasConceptScore W2468763224C2779134260 @default.
• W2468763224 hasConceptScore W2468763224C2779920096 @default.
• W2468763224 hasConceptScore W2468763224C2781065132 @default.

• next