FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468805276> ?p ?o ?g. }

• W2468805276 endingPage "016001" @default.
• W2468805276 startingPage "016001" @default.
• W2468805276 abstract "Coronary stenting is one of the most commonly used approaches to open coronary arteries blocked due to atherosclerosis. Stent malapposition can induce thrombosis but the microscopic process is poorly understood. The objective of this study was to determine the platelet-level process by which different extents of stent malapposition affect the initiation of stent thrombosis. We utilized a discrete element model to computationally simulate the transport, adhesion, and activation of thousands of individual platelets and red blood cells during thrombus initiation in stented coronary arteries. Simulated arteries contained a malapposed stent with a specified gap distance (0, 10, 25, 50, or 200 μm) between the struts and endothelium. Platelet-level details of thrombus formation near the proximal-most strut were measured during the simulations. The relationship between gap distance and amount of thrombus in the artery varied depending on different conditions (e.g., amount of dysfunctional endothelium, shear-induced activation of platelets, and thrombogenicity of the strut). Without considering shear-induced platelet activation, the largest gap distance (200 μm) produced no recirculation and less thrombus than the smallest two gap distances (0 and 10 μm) that created recirculation downstream of the strut. However, with the occurrence of shear-induced platelet activation, the largest gap distance produced more thrombus than the two smallest gap distances, but less thrombus than an intermediate gap distance (25 μm). A large gap distance was not necessarily the most thrombogenic, in contrast to implications of some computational fluid dynamics studies. The severity of stent malapposition affected initial stent thrombosis differently depending on various factors related to fluid recirculation, platelet trajectories, shear stress, and endothelial condition." @default.
• W2468805276 created "2016-07-22" @default.
• W2468805276 creator A5054753371 @default.
• W2468805276 creator A5058317572 @default.
• W2468805276 date "2016-01-20" @default.
• W2468805276 modified "2023-09-26" @default.
• W2468805276 title "Computational simulation of platelet interactions in the initiation of stent thrombosis due to stent malapposition" @default.
• W2468805276 cites W13897408 @default.
• W2468805276 cites W196677194 @default.
• W2468805276 cites W1983893864 @default.
• W2468805276 cites W1988542482 @default.
• W2468805276 cites W1992508185 @default.
• W2468805276 cites W1994275785 @default.
• W2468805276 cites W2005708795 @default.
• W2468805276 cites W2011338555 @default.
• W2468805276 cites W2012049557 @default.
• W2468805276 cites W2014922544 @default.
• W2468805276 cites W2018087797 @default.
• W2468805276 cites W2019350279 @default.
• W2468805276 cites W2024314380 @default.
• W2468805276 cites W2028402024 @default.
• W2468805276 cites W2029062376 @default.
• W2468805276 cites W2030181238 @default.
• W2468805276 cites W2030256176 @default.
• W2468805276 cites W2030405007 @default.
• W2468805276 cites W2034819228 @default.
• W2468805276 cites W2037238128 @default.
• W2468805276 cites W2039757012 @default.
• W2468805276 cites W2044806412 @default.
• W2468805276 cites W2049189170 @default.
• W2468805276 cites W2049911066 @default.
• W2468805276 cites W2052192720 @default.
• W2468805276 cites W2056093395 @default.
• W2468805276 cites W2058765771 @default.
• W2468805276 cites W2059181103 @default.
• W2468805276 cites W2065028046 @default.
• W2468805276 cites W2067670314 @default.
• W2468805276 cites W2069262230 @default.
• W2468805276 cites W2075631158 @default.
• W2468805276 cites W2077678786 @default.
• W2468805276 cites W2079741358 @default.
• W2468805276 cites W2080789876 @default.
• W2468805276 cites W2082408851 @default.
• W2468805276 cites W2082516191 @default.
• W2468805276 cites W2083619382 @default.
• W2468805276 cites W2085086801 @default.
• W2468805276 cites W2085564020 @default.
• W2468805276 cites W2087210962 @default.
• W2468805276 cites W2092434921 @default.
• W2468805276 cites W2093664148 @default.
• W2468805276 cites W2105530541 @default.
• W2468805276 cites W2106339559 @default.
• W2468805276 cites W2109585265 @default.
• W2468805276 cites W2110913624 @default.
• W2468805276 cites W2119286443 @default.
• W2468805276 cites W2124385743 @default.
• W2468805276 cites W2126797030 @default.
• W2468805276 cites W2128493116 @default.
• W2468805276 cites W2129447163 @default.
• W2468805276 cites W2129617136 @default.
• W2468805276 cites W2130055882 @default.
• W2468805276 cites W2146202010 @default.
• W2468805276 cites W2148169726 @default.
• W2468805276 cites W2148336158 @default.
• W2468805276 cites W2149790596 @default.
• W2468805276 cites W2151699920 @default.
• W2468805276 cites W2155892324 @default.
• W2468805276 cites W2158070111 @default.
• W2468805276 cites W2168575889 @default.
• W2468805276 cites W2547338502 @default.
• W2468805276 cites W4254297790 @default.
• W2468805276 cites W4255813750 @default.
• W2468805276 doi "https://doi.org/10.1088/1478-3975/13/1/016001" @default.
• W2468805276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5039126" @default.
• W2468805276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26790093" @default.
• W2468805276 hasPublicationYear "2016" @default.
• W2468805276 type Work @default.
• W2468805276 sameAs 2468805276 @default.
• W2468805276 citedByCount "21" @default.
• W2468805276 countsByYear W24688052762017 @default.
• W2468805276 countsByYear W24688052762018 @default.
• W2468805276 countsByYear W24688052762019 @default.
• W2468805276 countsByYear W24688052762020 @default.
• W2468805276 countsByYear W24688052762021 @default.
• W2468805276 countsByYear W24688052762022 @default.
• W2468805276 crossrefType "journal-article" @default.
• W2468805276 hasAuthorship W2468805276A5054753371 @default.
• W2468805276 hasAuthorship W2468805276A5058317572 @default.
• W2468805276 hasBestOaLocation W24688052762 @default.
• W2468805276 hasConcept C126322002 @default.
• W2468805276 hasConcept C136229726 @default.
• W2468805276 hasConcept C164705383 @default.
• W2468805276 hasConcept C2776649359 @default.
• W2468805276 hasConcept C2776820930 @default.
• W2468805276 hasConcept C2778583881 @default.
• W2468805276 hasConcept C2778742706 @default.
• W2468805276 hasConcept C2780868729 @default.
• W2468805276 hasConcept C2781362458 @default.

• next