FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468832013> ?p ?o ?g. }

• W2468832013 endingPage "1905" @default.
• W2468832013 startingPage "1889" @default.
• W2468832013 abstract "Lactobacillus rhamnosus is a diverse Gram-positive species with strains isolated from different ecological niches. Here, we report the genome sequence analysis of 40 diverse strains of L. rhamnosus and their genomic comparison, with a focus on the variable genome. Genomic comparison of 40 L. rhamnosus strains discriminated the conserved genes (core genome) and regions of plasticity involving frequent rearrangements and horizontal transfer (variome). The L. rhamnosus core genome encompasses 2,164 genes, out of 4,711 genes in total (the pan-genome). The accessory genome is dominated by genes encoding carbohydrate transport and metabolism, extracellular polysaccharides (EPS) biosynthesis, bacteriocin production, pili production, the cas system, and the associated clustered regularly interspaced short palindromic repeat (CRISPR) loci, and more than 100 transporter functions and mobile genetic elements like phages, plasmid genes, and transposons. A clade distribution based on amino acid differences between core (shared) proteins matched with the clade distribution obtained from the presence–absence of variable genes. The phylogenetic and variome tree overlap indicated that frequent events of gene acquisition and loss dominated the evolutionary segregation of the strains within this species, which is paralleled by evolutionary diversification of core gene functions. The CRISPR-Cas system could have contributed to this evolutionary segregation. Lactobacillus rhamnosus strains contain the genetic and metabolic machinery with strain-specific gene functions required to adapt to a large range of environments. A remarkable congruency of the evolutionary relatedness of the strains’ core and variome functions, possibly favoring interspecies genetic exchanges, underlines the importance of gene-acquisition and loss within the L. rhamnosus strain diversification." @default.
• W2468832013 created "2016-07-22" @default.
• W2468832013 creator A5009866847 @default.
• W2468832013 creator A5017026987 @default.
• W2468832013 creator A5042034745 @default.
• W2468832013 creator A5049979001 @default.
• W2468832013 creator A5054572740 @default.
• W2468832013 creator A5063076124 @default.
• W2468832013 creator A5063196220 @default.
• W2468832013 creator A5067535218 @default.
• W2468832013 creator A5070232254 @default.
• W2468832013 creator A5080388447 @default.
• W2468832013 date "2016-06-01" @default.
• W2468832013 modified "2023-10-17" @default.
• W2468832013 title "The Variable Regions of<i>Lactobacillus rhamnosus</i>Genomes Reveal the Dynamic Evolution of Metabolic and Host-Adaptation Repertoires" @default.
• W2468832013 cites W136650183 @default.
• W2468832013 cites W1519266993 @default.
• W2468832013 cites W1770039048 @default.
• W2468832013 cites W1775386391 @default.
• W2468832013 cites W1956336427 @default.
• W2468832013 cites W1964632276 @default.
• W2468832013 cites W1966138458 @default.
• W2468832013 cites W1971656321 @default.
• W2468832013 cites W1977445540 @default.
• W2468832013 cites W1980030331 @default.
• W2468832013 cites W1987459572 @default.
• W2468832013 cites W1990852600 @default.
• W2468832013 cites W1991716343 @default.
• W2468832013 cites W1995318677 @default.
• W2468832013 cites W1995438737 @default.
• W2468832013 cites W1998384572 @default.
• W2468832013 cites W1999291944 @default.
• W2468832013 cites W2001397592 @default.
• W2468832013 cites W2006716355 @default.
• W2468832013 cites W2010986636 @default.
• W2468832013 cites W2011559159 @default.
• W2468832013 cites W2013162744 @default.
• W2468832013 cites W2015701509 @default.
• W2468832013 cites W2019623246 @default.
• W2468832013 cites W2022366078 @default.
• W2468832013 cites W2023752536 @default.
• W2468832013 cites W2024226631 @default.
• W2468832013 cites W2026616615 @default.
• W2468832013 cites W2027426795 @default.
• W2468832013 cites W2027831845 @default.
• W2468832013 cites W2034871089 @default.
• W2468832013 cites W2035218417 @default.
• W2468832013 cites W2035591992 @default.
• W2468832013 cites W2037254934 @default.
• W2468832013 cites W2038683612 @default.
• W2468832013 cites W2043039151 @default.
• W2468832013 cites W2052883442 @default.
• W2468832013 cites W2053740412 @default.
• W2468832013 cites W2054859059 @default.
• W2468832013 cites W2056138501 @default.
• W2468832013 cites W2058479248 @default.
• W2468832013 cites W2066021029 @default.
• W2468832013 cites W2066854880 @default.
• W2468832013 cites W2072767450 @default.
• W2468832013 cites W2084937356 @default.
• W2468832013 cites W2085886379 @default.
• W2468832013 cites W2089768917 @default.
• W2468832013 cites W2091030812 @default.
• W2468832013 cites W2097272177 @default.
• W2468832013 cites W2098205840 @default.
• W2468832013 cites W2098356192 @default.
• W2468832013 cites W2098466396 @default.
• W2468832013 cites W2102672175 @default.
• W2468832013 cites W2103384450 @default.
• W2468832013 cites W2104330483 @default.
• W2468832013 cites W2107758049 @default.
• W2468832013 cites W2107903949 @default.
• W2468832013 cites W2108828818 @default.
• W2468832013 cites W2111211467 @default.
• W2468832013 cites W2114658582 @default.
• W2468832013 cites W2119914998 @default.
• W2468832013 cites W2122326506 @default.
• W2468832013 cites W2124351063 @default.
• W2468832013 cites W2124380017 @default.
• W2468832013 cites W2127391962 @default.
• W2468832013 cites W2127489580 @default.
• W2468832013 cites W2129521636 @default.
• W2468832013 cites W2130408443 @default.
• W2468832013 cites W2133579817 @default.
• W2468832013 cites W2139224067 @default.
• W2468832013 cites W2139431084 @default.
• W2468832013 cites W2140983229 @default.
• W2468832013 cites W2141637710 @default.
• W2468832013 cites W2142428670 @default.
• W2468832013 cites W2145704137 @default.
• W2468832013 cites W2146381852 @default.
• W2468832013 cites W2147315393 @default.
• W2468832013 cites W2148656457 @default.
• W2468832013 cites W2148666143 @default.
• W2468832013 cites W2148687236 @default.
• W2468832013 cites W2152900584 @default.
• W2468832013 cites W2156270624 @default.
• W2468832013 cites W2158714788 @default.

• next