FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2468876663> ?p ?o ?g. }

• W2468876663 abstract "BACKGROUND & AIMS: Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation. Main contributors to increased IP are ammonia, glutamine, edema, and blood flow. The sequence of events and underlying mechanisms, as well as the temporal pattern, regional distribution, and contribution of each parameter to the progression of neurologic deterioration and IP, are unclear. We studied rats with ALF to follow the progression of changes in ammonia, glutamine, grade and type (vasogenic or cytotoxic) of edema, blood-brain barrier permeability, cerebral blood flow, and IP. We assessed whether the changes in these parameters were similar between frontal cortex and cerebellum and evaluated the presence, type, and progression of edema in 12 brain areas. METHODS: ALF was induced by injection of galactosamine. The grade and type of edema was assessed by measuring the apparent diffusion coefficient by magnetic resonance imaging. Cerebral blood flow was measured by magnetic resonance and blood-brain barrier permeability by Evans blue‐albumin extravasation. RESULTS: Increased IP arises from an early increase of blood‐brain barrier permeability in certain areas (including cerebellum but not frontal cortex) followed by vasogenic edema. Ammonia and glutamine then increase progressively, leading to cytotoxic edema in many areas. Alterations in lactate and cerebral blood flow are later events that further increase IP. CONCLUSIONS: Different mechanisms in specific regions of the brain contribute, with different temporal patterns, to the progression of cerebral alterations and IP in ALF." @default.
• W2468876663 created "2016-07-22" @default.
• W2468876663 creator A5008602040 @default.
• W2468876663 creator A5013632545 @default.
• W2468876663 creator A5017985316 @default.
• W2468876663 creator A5047619169 @default.
• W2468876663 creator A5072998448 @default.
• W2468876663 creator A5077701327 @default.
• W2468876663 date "2011-01-01" @default.
• W2468876663 modified "2023-10-16" @default.
• W2468876663 title "BASIC—LIVER, PANCREAS, AND BILIARY TRACT Brain Region-Selective Mechanisms Contribute to the Progression of Cerebral Alterations in Acute Liver Failure in Rats" @default.
• W2468876663 cites W1608390320 @default.
• W2468876663 cites W1799449456 @default.
• W2468876663 cites W1893412287 @default.
• W2468876663 cites W1968262998 @default.
• W2468876663 cites W1969248415 @default.
• W2468876663 cites W1975751578 @default.
• W2468876663 cites W1978643508 @default.
• W2468876663 cites W1982756976 @default.
• W2468876663 cites W1987080089 @default.
• W2468876663 cites W1993391356 @default.
• W2468876663 cites W1994759361 @default.
• W2468876663 cites W2000773358 @default.
• W2468876663 cites W2003762635 @default.
• W2468876663 cites W2042295479 @default.
• W2468876663 cites W2042823827 @default.
• W2468876663 cites W2044980894 @default.
• W2468876663 cites W2046209778 @default.
• W2468876663 cites W2047717681 @default.
• W2468876663 cites W2057305034 @default.
• W2468876663 cites W2062170934 @default.
• W2468876663 cites W2066134367 @default.
• W2468876663 cites W2069979635 @default.
• W2468876663 cites W2070225650 @default.
• W2468876663 cites W2071411051 @default.
• W2468876663 cites W2087245233 @default.
• W2468876663 cites W2115417400 @default.
• W2468876663 cites W2115721699 @default.
• W2468876663 cites W2116188145 @default.
• W2468876663 cites W2118525371 @default.
• W2468876663 cites W2138478614 @default.
• W2468876663 cites W2163815564 @default.
• W2468876663 cites W2166426232 @default.
• W2468876663 cites W224682340 @default.
• W2468876663 cites W2338871610 @default.
• W2468876663 cites W2412777302 @default.
• W2468876663 cites W93496947 @default.
• W2468876663 cites W2023629631 @default.
• W2468876663 hasPublicationYear "2011" @default.
• W2468876663 type Work @default.
• W2468876663 sameAs 2468876663 @default.
• W2468876663 citedByCount "0" @default.
• W2468876663 crossrefType "journal-article" @default.
• W2468876663 hasAuthorship W2468876663A5008602040 @default.
• W2468876663 hasAuthorship W2468876663A5013632545 @default.
• W2468876663 hasAuthorship W2468876663A5017985316 @default.
• W2468876663 hasAuthorship W2468876663A5047619169 @default.
• W2468876663 hasAuthorship W2468876663A5072998448 @default.
• W2468876663 hasAuthorship W2468876663A5077701327 @default.
• W2468876663 hasConcept C126322002 @default.
• W2468876663 hasConcept C126838900 @default.
• W2468876663 hasConcept C142724271 @default.
• W2468876663 hasConcept C143409427 @default.
• W2468876663 hasConcept C157767197 @default.
• W2468876663 hasConcept C185592680 @default.
• W2468876663 hasConcept C2777214474 @default.
• W2468876663 hasConcept C2777649898 @default.
• W2468876663 hasConcept C2778402981 @default.
• W2468876663 hasConcept C2779349466 @default.
• W2468876663 hasConcept C2779493303 @default.
• W2468876663 hasConcept C2779540182 @default.
• W2468876663 hasConcept C2779652256 @default.
• W2468876663 hasConcept C2780325230 @default.
• W2468876663 hasConcept C2780886150 @default.
• W2468876663 hasConcept C515207424 @default.
• W2468876663 hasConcept C529278444 @default.
• W2468876663 hasConcept C55493867 @default.
• W2468876663 hasConcept C70816921 @default.
• W2468876663 hasConcept C71924100 @default.
• W2468876663 hasConceptScore W2468876663C126322002 @default.
• W2468876663 hasConceptScore W2468876663C126838900 @default.
• W2468876663 hasConceptScore W2468876663C142724271 @default.
• W2468876663 hasConceptScore W2468876663C143409427 @default.
• W2468876663 hasConceptScore W2468876663C157767197 @default.
• W2468876663 hasConceptScore W2468876663C185592680 @default.
• W2468876663 hasConceptScore W2468876663C2777214474 @default.
• W2468876663 hasConceptScore W2468876663C2777649898 @default.
• W2468876663 hasConceptScore W2468876663C2778402981 @default.
• W2468876663 hasConceptScore W2468876663C2779349466 @default.
• W2468876663 hasConceptScore W2468876663C2779493303 @default.
• W2468876663 hasConceptScore W2468876663C2779540182 @default.
• W2468876663 hasConceptScore W2468876663C2779652256 @default.
• W2468876663 hasConceptScore W2468876663C2780325230 @default.
• W2468876663 hasConceptScore W2468876663C2780886150 @default.
• W2468876663 hasConceptScore W2468876663C515207424 @default.
• W2468876663 hasConceptScore W2468876663C529278444 @default.
• W2468876663 hasConceptScore W2468876663C55493867 @default.
• W2468876663 hasConceptScore W2468876663C70816921 @default.
• W2468876663 hasConceptScore W2468876663C71924100 @default.
• W2468876663 hasLocation W24688766631 @default.

• next