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• W2468996925 endingPage "2013" @default.
• W2468996925 startingPage "2005" @default.
• W2468996925 abstract "CC chemokine receptor 3 (CCR3) is expressed selectively in eosinophils, basophils, and some Th2 cells and plays a major role in allergic diseases. A methanol extract from the arils of Myristica fragrans inhibited CC chemokine ligand 11-induced chemotaxis in CCR3-expressing L1.2 cells at 100 μg/mL. From this extract, eight new neolignans, maceneolignans A–H (1–8), were isolated, and their stereostructures were elucidated from their spectroscopic values and chemical properties. Of those constituents, compounds 1, 4, 6, and 8 and (+)-erythro-(7S,8R)-Δ8′-7-hydroxy-3,4-methylenedioxy-3′,5′-dimethoxy-8-O-4′-neolignan (11), (−)-(8R)-Δ8′-3,4-methylenedioxy-3′,5′-dimethoxy-8-O-4′-neolignan (17), (+)-licarin A (20), nectandrin B (25), verrucosin (26), and myristicin (27) inhibited CCR3-mediated chemotaxis at a concentration of 1 μM. Among them, 1 (EC50 1.6 μM), 6 (1.5 μM), and 8 (1.4 μM) showed relatively strong activities, which were comparable to that of a synthetic CCR3 selective antagonist, SB328437 (0.78 μM)." @default.
• W2468996925 created "2016-07-22" @default.
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• W2468996925 date "2016-07-15" @default.
• W2468996925 modified "2023-10-09" @default.
• W2468996925 title "Neolignans from the Arils of <i>Myristica fragrans</i> as Potent Antagonists of CC Chemokine Receptor 3" @default.
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• W2468996925 doi "https://doi.org/10.1021/acs.jnatprod.6b00262" @default.
• W2468996925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27419473" @default.
• W2468996925 hasPublicationYear "2016" @default.
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