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• W2469094794 abstract "Abstract In acute myeloid leukemia (AML), the Fms-like tyrosine kinase 3 ( FLT3) is one of the most frequently mutated genes. Recently, a new and recurrent juxtamembrane deletion mutation (p.Q569Vfs*2) resulting in a truncated receptor was identified. The mutated receptor is expressed on the cell surface and still binds its ligand but loses the ability to activate ERK signaling. FLT3 p.Q569fs-expressing Ba/F3 cells show no proliferation after ligand stimulation. Furthermore, coexpressed with the FLT3 wild-type (WT) receptor, the truncated receptor suppresses stimulation and activation of the WT receptor. Thus, FLT3 p.Q569Vfs*2, to our knowledge, is the first FLT3 mutation with a dominant negative effect on the WT receptor." @default.
• W2469094794 created "2016-07-22" @default.
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• W2469094794 date "2016-06-27" @default.
• W2469094794 modified "2023-09-27" @default.
• W2469094794 title "The new and recurrent FLT3 juxtamembrane deletion mutation shows a dominant negative effect on the wild-type FLT3 receptor" @default.
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• W2469094794 doi "https://doi.org/10.1038/srep28032" @default.
• W2469094794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4921855" @default.
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• W2469094794 hasPublicationYear "2016" @default.
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