FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2469237089> ?p ?o ?g. }

• W2469237089 endingPage "298" @default.
• W2469237089 startingPage "289" @default.
• W2469237089 abstract "Alzheimer’s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists’ attention because of its complexity. The last 30 years have been filled with discoveries regarding the elusive aetiology of this disease and, thanks to advances in molecular biology and live imaging techniques, we now know that an important role is played by calcium (Ca2+). Ca2+, as ubiquitous second messenger, regulates a vast variety of cellular processes, from neuronal excitation and communication, to muscle fibre contraction and hormone secretion, with its action spanning a temporal scale that goes from microseconds to hours. It is therefore very challenging to conceive a single hypothesis that can integrate the numerous findings on this issue with those coming from the classical fields of AD research such as amyloid-beta (Aβ) and tau pathology. In this contribution, we will focus our attention on the Ca2+ hypothesis of AD, dissecting it, as much as possible, in its subcellular localization, where the Ca2+ signal meets its specificity. We will also follow the temporal evolution of the Ca2+ hypothesis, providing some of the most updated discoveries. Whenever possible, we will link the findings regarding Ca2+ dysfunction to the other players involved in AD pathogenesis, hoping to provide a crossover body of evidence, useful to amplify the knowledge that will lead towards the discovery of an effective therapy." @default.
• W2469237089 created "2016-07-22" @default.
• W2469237089 creator A5032894425 @default.
• W2469237089 creator A5061145894 @default.
• W2469237089 date "2016-11-01" @default.
• W2469237089 modified "2023-09-23" @default.
• W2469237089 title "When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer’s Disease" @default.
• W2469237089 cites W106731548 @default.
• W2469237089 cites W1149434589 @default.
• W2469237089 cites W1497413049 @default.
• W2469237089 cites W1513242172 @default.
• W2469237089 cites W1745482744 @default.
• W2469237089 cites W1803199265 @default.
• W2469237089 cites W1859821439 @default.
• W2469237089 cites W1951572307 @default.
• W2469237089 cites W1962539546 @default.
• W2469237089 cites W1965451351 @default.
• W2469237089 cites W1966100017 @default.
• W2469237089 cites W1970049338 @default.
• W2469237089 cites W1970399273 @default.
• W2469237089 cites W1970734834 @default.
• W2469237089 cites W1972965665 @default.
• W2469237089 cites W1976118830 @default.
• W2469237089 cites W1978582104 @default.
• W2469237089 cites W1978898945 @default.
• W2469237089 cites W1980825524 @default.
• W2469237089 cites W1981762416 @default.
• W2469237089 cites W1982695759 @default.
• W2469237089 cites W1982706802 @default.
• W2469237089 cites W1982815320 @default.
• W2469237089 cites W1985060509 @default.
• W2469237089 cites W1985452716 @default.
• W2469237089 cites W1988499586 @default.
• W2469237089 cites W1989142174 @default.
• W2469237089 cites W1991347226 @default.
• W2469237089 cites W1992606600 @default.
• W2469237089 cites W2001731317 @default.
• W2469237089 cites W2004583891 @default.
• W2469237089 cites W2005695597 @default.
• W2469237089 cites W2006339817 @default.
• W2469237089 cites W2007706380 @default.
• W2469237089 cites W2010550564 @default.
• W2469237089 cites W2016323146 @default.
• W2469237089 cites W2020460747 @default.
• W2469237089 cites W2021740591 @default.
• W2469237089 cites W2023164919 @default.
• W2469237089 cites W2023200476 @default.
• W2469237089 cites W2023886341 @default.
• W2469237089 cites W2027131229 @default.
• W2469237089 cites W2027616725 @default.
• W2469237089 cites W2029181104 @default.
• W2469237089 cites W2029668693 @default.
• W2469237089 cites W2030650261 @default.
• W2469237089 cites W2035270874 @default.
• W2469237089 cites W2035466313 @default.
• W2469237089 cites W2035763500 @default.
• W2469237089 cites W2038906428 @default.
• W2469237089 cites W2039552657 @default.
• W2469237089 cites W2040252592 @default.
• W2469237089 cites W2040840038 @default.
• W2469237089 cites W2041253676 @default.
• W2469237089 cites W2041956586 @default.
• W2469237089 cites W2044842056 @default.
• W2469237089 cites W2044904524 @default.
• W2469237089 cites W2045270516 @default.
• W2469237089 cites W2048685634 @default.
• W2469237089 cites W2050364555 @default.
• W2469237089 cites W2053665966 @default.
• W2469237089 cites W2056007810 @default.
• W2469237089 cites W2060823097 @default.
• W2469237089 cites W2061342941 @default.
• W2469237089 cites W2065432433 @default.
• W2469237089 cites W2067960353 @default.
• W2469237089 cites W2068835565 @default.
• W2469237089 cites W2069274491 @default.
• W2469237089 cites W2069888362 @default.
• W2469237089 cites W2071540691 @default.
• W2469237089 cites W2072625029 @default.
• W2469237089 cites W2073296995 @default.
• W2469237089 cites W2075481535 @default.
• W2469237089 cites W2076968916 @default.
• W2469237089 cites W2080556515 @default.
• W2469237089 cites W2081263409 @default.
• W2469237089 cites W2084972185 @default.
• W2469237089 cites W2084973310 @default.
• W2469237089 cites W2085287800 @default.
• W2469237089 cites W2087733977 @default.
• W2469237089 cites W2088034288 @default.
• W2469237089 cites W2089074324 @default.
• W2469237089 cites W2089963291 @default.
• W2469237089 cites W2093753108 @default.
• W2469237089 cites W2093800329 @default.
• W2469237089 cites W2095218710 @default.
• W2469237089 cites W2096336861 @default.
• W2469237089 cites W2096410114 @default.
• W2469237089 cites W2097095684 @default.
• W2469237089 cites W2097226847 @default.
• W2469237089 cites W2099970570 @default.

• next