Matches in SemOpenAlex for { <https://semopenalex.org/work/W2469265555> ?p ?o ?g. }
- W2469265555 abstract "Whereas tumorigenic processes have traditionally been attributed to gene amplification, deletion, or mutation, it is now clear that epigenetic changes represent an additional hallmark of cancer. This review explains the basic principles of epigenetic regulation and therapy, provides an overview of clinically approved drugs, introduces novel targets and compounds, and discusses the potential reasons behind treatment success and failure.We provide a brief introduction to the concept of epigenetic regulation in general and explain how epigenetic pathways are altered in cancer. Based on this, we go on to explore the rational behind epigenetic cancer therapy, provide an overview of clinical success and failure of specific drugs, describe novel pharmaceutical targets, review epigenetic combination treatment, and finally discuss biological concepts influencing treatment success. Expert commentary: Even though many early epigenetic therapy trials had disappointing results, lessons learned from these studies have heavily influenced the design of modern trials leading to improved therapeutic outcomes. Better preclinical model systems may help to reduce the risk of clinical failure and to identify high-confidence targets for clinical follow-up." @default.
- W2469265555 created "2016-07-22" @default.
- W2469265555 creator A5036252189 @default.
- W2469265555 creator A5089833949 @default.
- W2469265555 date "2016-08-05" @default.
- W2469265555 modified "2023-09-24" @default.
- W2469265555 title "Rewiring the solid tumor epigenome for cancer therapy" @default.
- W2469265555 cites W1691796058 @default.
- W2469265555 cites W1874881634 @default.
- W2469265555 cites W1917736788 @default.
- W2469265555 cites W1941548156 @default.
- W2469265555 cites W1967803195 @default.
- W2469265555 cites W1968218520 @default.
- W2469265555 cites W1968294652 @default.
- W2469265555 cites W1972076975 @default.
- W2469265555 cites W1973059973 @default.
- W2469265555 cites W1974359182 @default.
- W2469265555 cites W1974747095 @default.
- W2469265555 cites W1978419388 @default.
- W2469265555 cites W1982454947 @default.
- W2469265555 cites W1985180051 @default.
- W2469265555 cites W1989421786 @default.
- W2469265555 cites W1989987919 @default.
- W2469265555 cites W1990381590 @default.
- W2469265555 cites W1991903960 @default.
- W2469265555 cites W1992127633 @default.
- W2469265555 cites W1992902970 @default.
- W2469265555 cites W1993463141 @default.
- W2469265555 cites W1996036500 @default.
- W2469265555 cites W1996874832 @default.
- W2469265555 cites W2003872705 @default.
- W2469265555 cites W2007639313 @default.
- W2469265555 cites W2007704672 @default.
- W2469265555 cites W2013816626 @default.
- W2469265555 cites W2017985800 @default.
- W2469265555 cites W2019173523 @default.
- W2469265555 cites W2024848067 @default.
- W2469265555 cites W2029385426 @default.
- W2469265555 cites W2029868343 @default.
- W2469265555 cites W2029874395 @default.
- W2469265555 cites W2034156554 @default.
- W2469265555 cites W2034882046 @default.
- W2469265555 cites W2035731408 @default.
- W2469265555 cites W2041535798 @default.
- W2469265555 cites W2043148368 @default.
- W2469265555 cites W2044551569 @default.
- W2469265555 cites W2044721366 @default.
- W2469265555 cites W2046345187 @default.
- W2469265555 cites W2051626631 @default.
- W2469265555 cites W2054621094 @default.
- W2469265555 cites W2054643318 @default.
- W2469265555 cites W2059059097 @default.
- W2469265555 cites W2060446375 @default.
- W2469265555 cites W2068157186 @default.
- W2469265555 cites W2068205741 @default.
- W2469265555 cites W2071100278 @default.
- W2469265555 cites W2071951670 @default.
- W2469265555 cites W2073320078 @default.
- W2469265555 cites W2075625882 @default.
- W2469265555 cites W2077166822 @default.
- W2469265555 cites W2077981176 @default.
- W2469265555 cites W2078972833 @default.
- W2469265555 cites W2081159709 @default.
- W2469265555 cites W2086492419 @default.
- W2469265555 cites W2087493660 @default.
- W2469265555 cites W2089625272 @default.
- W2469265555 cites W2089704159 @default.
- W2469265555 cites W2092476693 @default.
- W2469265555 cites W2095124748 @default.
- W2469265555 cites W2096367061 @default.
- W2469265555 cites W2101117526 @default.
- W2469265555 cites W2104425103 @default.
- W2469265555 cites W2105085478 @default.
- W2469265555 cites W2105528101 @default.
- W2469265555 cites W2106292925 @default.
- W2469265555 cites W2106584820 @default.
- W2469265555 cites W2107733280 @default.
- W2469265555 cites W2108017291 @default.
- W2469265555 cites W2108408221 @default.
- W2469265555 cites W2109710744 @default.
- W2469265555 cites W2113225141 @default.
- W2469265555 cites W2115593774 @default.
- W2469265555 cites W2118771330 @default.
- W2469265555 cites W2118937292 @default.
- W2469265555 cites W2126740719 @default.
- W2469265555 cites W2131233619 @default.
- W2469265555 cites W2132037667 @default.
- W2469265555 cites W2135953007 @default.
- W2469265555 cites W2139024794 @default.
- W2469265555 cites W2139077902 @default.
- W2469265555 cites W2145750252 @default.
- W2469265555 cites W2145919968 @default.
- W2469265555 cites W2145940442 @default.
- W2469265555 cites W2147524392 @default.
- W2469265555 cites W2156038562 @default.
- W2469265555 cites W2158998217 @default.
- W2469265555 cites W2162354443 @default.
- W2469265555 cites W2163259627 @default.
- W2469265555 cites W2163394167 @default.
- W2469265555 cites W2164738877 @default.