Matches in SemOpenAlex for { <https://semopenalex.org/work/W2469348535> ?p ?o ?g. }
- W2469348535 abstract "Sox2 is a pluripotency transcription factor that as an oncogene can also regulate cell proliferation. Therefore, genes implicated in several different aspects of cell proliferation, such as the VRK1 chromatin-kinase, are candidates to be targets of Sox2. Sox 2 and VRK1 colocalize in nuclei of proliferating cells forming a stable complex. Sox2 knockdown abrogates VRK1 gene expression. Depletion of either Sox2 or VRK1 caused a reduction of cell proliferation. Sox2 up-regulates VRK1 expression and both proteins cooperate in the activation of CCND1. The accumulation of VRK1 protein downregulates SOX2 expression and both proteins are lost in terminally differentiated cells. Induction of neural differentiation with retinoic acid resulted in downregulation of Sox2 and VRK1 that inversely correlated with the expression of differentiation markers such as N-cadherin, Pax6, mH2A1.2 and mH2A2. Differentiation-associated macro histones mH2A1.2and mH2A2 inhibit CCND1 and VRK1 expression and also block the activation of the VRK1 promoter by Sox2. VRK1 is a downstream target of Sox2 and both form an autoregulatory loop in epithelial cell differentiation." @default.
- W2469348535 created "2016-07-22" @default.
- W2469348535 creator A5005498435 @default.
- W2469348535 creator A5006947975 @default.
- W2469348535 creator A5009957675 @default.
- W2469348535 creator A5010372223 @default.
- W2469348535 creator A5010685420 @default.
- W2469348535 creator A5011280844 @default.
- W2469348535 creator A5081782756 @default.
- W2469348535 date "2016-06-23" @default.
- W2469348535 modified "2023-10-14" @default.
- W2469348535 title "Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation" @default.
- W2469348535 cites W1023090330 @default.
- W2469348535 cites W1518966340 @default.
- W2469348535 cites W1538089655 @default.
- W2469348535 cites W1560447611 @default.
- W2469348535 cites W1776914999 @default.
- W2469348535 cites W1966678470 @default.
- W2469348535 cites W1967289736 @default.
- W2469348535 cites W1967761437 @default.
- W2469348535 cites W1967768414 @default.
- W2469348535 cites W1967835379 @default.
- W2469348535 cites W1973807140 @default.
- W2469348535 cites W1977656230 @default.
- W2469348535 cites W1978425667 @default.
- W2469348535 cites W1992772703 @default.
- W2469348535 cites W1999553354 @default.
- W2469348535 cites W1999598905 @default.
- W2469348535 cites W2002890978 @default.
- W2469348535 cites W2004241887 @default.
- W2469348535 cites W2007962137 @default.
- W2469348535 cites W2014130784 @default.
- W2469348535 cites W2022040474 @default.
- W2469348535 cites W2022064228 @default.
- W2469348535 cites W2023171799 @default.
- W2469348535 cites W2024876545 @default.
- W2469348535 cites W2038356000 @default.
- W2469348535 cites W2043764521 @default.
- W2469348535 cites W2045451799 @default.
- W2469348535 cites W2046024621 @default.
- W2469348535 cites W2054806698 @default.
- W2469348535 cites W2059521716 @default.
- W2469348535 cites W2067523605 @default.
- W2469348535 cites W2068098232 @default.
- W2469348535 cites W2073759231 @default.
- W2469348535 cites W2077987278 @default.
- W2469348535 cites W2079777624 @default.
- W2469348535 cites W2081100502 @default.
- W2469348535 cites W2083146650 @default.
- W2469348535 cites W2084345288 @default.
- W2469348535 cites W2084454249 @default.
- W2469348535 cites W2087476954 @default.
- W2469348535 cites W2088127789 @default.
- W2469348535 cites W2102554713 @default.
- W2469348535 cites W2104843183 @default.
- W2469348535 cites W2106978201 @default.
- W2469348535 cites W2111511846 @default.
- W2469348535 cites W2115250513 @default.
- W2469348535 cites W2115509391 @default.
- W2469348535 cites W2119526608 @default.
- W2469348535 cites W2123194197 @default.
- W2469348535 cites W2124498519 @default.
- W2469348535 cites W2125987139 @default.
- W2469348535 cites W2130043237 @default.
- W2469348535 cites W2131559143 @default.
- W2469348535 cites W2133440494 @default.
- W2469348535 cites W2133532796 @default.
- W2469348535 cites W2138541870 @default.
- W2469348535 cites W2139334516 @default.
- W2469348535 cites W2139596383 @default.
- W2469348535 cites W2141797256 @default.
- W2469348535 cites W2145877883 @default.
- W2469348535 cites W2148394396 @default.
- W2469348535 cites W2149630882 @default.
- W2469348535 cites W2152907403 @default.
- W2469348535 cites W2157615753 @default.
- W2469348535 cites W2164075697 @default.
- W2469348535 cites W2167281518 @default.
- W2469348535 cites W2169197097 @default.
- W2469348535 cites W2170520206 @default.
- W2469348535 doi "https://doi.org/10.1038/srep28532" @default.
- W2469348535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4917848" @default.
- W2469348535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27334688" @default.
- W2469348535 hasPublicationYear "2016" @default.
- W2469348535 type Work @default.
- W2469348535 sameAs 2469348535 @default.
- W2469348535 citedByCount "14" @default.
- W2469348535 countsByYear W24693485352016 @default.
- W2469348535 countsByYear W24693485352017 @default.
- W2469348535 countsByYear W24693485352018 @default.
- W2469348535 countsByYear W24693485352019 @default.
- W2469348535 countsByYear W24693485352020 @default.
- W2469348535 countsByYear W24693485352021 @default.
- W2469348535 crossrefType "journal-article" @default.
- W2469348535 hasAuthorship W2469348535A5005498435 @default.
- W2469348535 hasAuthorship W2469348535A5006947975 @default.
- W2469348535 hasAuthorship W2469348535A5009957675 @default.
- W2469348535 hasAuthorship W2469348535A5010372223 @default.
- W2469348535 hasAuthorship W2469348535A5010685420 @default.
- W2469348535 hasAuthorship W2469348535A5011280844 @default.