Matches in SemOpenAlex for { <https://semopenalex.org/work/W2469378041> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2469378041 endingPage "7" @default.
- W2469378041 startingPage "120" @default.
- W2469378041 abstract "Extensive research has been carried out in the last years to try to prevent graft rejection by minimizing the side effects related to the use of immunosuppressants. Ideally, one would hope to achieve a state of donor-specific unresponsiveness in order to promote a condition of true tolerance without the need of immunosuppressants. Recent evidence has been provided that this is a pursuing goal, at least in experimental animals, and even in humans increasing data are available that tolerance is achieved in some patients years after transplantation. The interest in donor-specific transplant tolerance has been renewed by the recent observations that in the rat the thymus is an immunologically privileged site into which isolated pancreatic islets can be engrafted and survive indefinitely. Moreover, intrathymic injection induced donor-specific unresponsiveness, which allowed survival of a second donor-strain islet cell allograft transplanted into an extrathymic site. Findings on cellular allograft have been extended to vascularized organ allografts. Recent experiments documented that in the rat intrathymic injection of donor cells allows subsequent renal graft to survive indefinitely. Unresponsiveness to rat kidney graft is donor but not tissue specific and evidence is presented here that the thymus has a central role in such a phenomenon. Hopefully, these studies will open new perspectives in transplantation promoting indefinite graft survival without the complications of long-term immunosuppressants." @default.
- W2469378041 created "2016-07-22" @default.
- W2469378041 creator A5033209784 @default.
- W2469378041 creator A5039199295 @default.
- W2469378041 creator A5076316519 @default.
- W2469378041 date "1993-03-01" @default.
- W2469378041 modified "2023-09-23" @default.
- W2469378041 title "Studies of privileged sites and organ transplantation." @default.
- W2469378041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8081956" @default.
- W2469378041 hasPublicationYear "1993" @default.
- W2469378041 type Work @default.
- W2469378041 sameAs 2469378041 @default.
- W2469378041 citedByCount "2" @default.
- W2469378041 crossrefType "journal-article" @default.
- W2469378041 hasAuthorship W2469378041A5033209784 @default.
- W2469378041 hasAuthorship W2469378041A5039199295 @default.
- W2469378041 hasAuthorship W2469378041A5076316519 @default.
- W2469378041 hasConcept C109159458 @default.
- W2469378041 hasConcept C126322002 @default.
- W2469378041 hasConcept C147483822 @default.
- W2469378041 hasConcept C165220095 @default.
- W2469378041 hasConcept C203014093 @default.
- W2469378041 hasConcept C2777702733 @default.
- W2469378041 hasConcept C2779306644 @default.
- W2469378041 hasConcept C2780091579 @default.
- W2469378041 hasConcept C28328180 @default.
- W2469378041 hasConcept C2908554679 @default.
- W2469378041 hasConcept C2911091166 @default.
- W2469378041 hasConcept C2993713153 @default.
- W2469378041 hasConcept C71924100 @default.
- W2469378041 hasConcept C86803240 @default.
- W2469378041 hasConcept C95444343 @default.
- W2469378041 hasConceptScore W2469378041C109159458 @default.
- W2469378041 hasConceptScore W2469378041C126322002 @default.
- W2469378041 hasConceptScore W2469378041C147483822 @default.
- W2469378041 hasConceptScore W2469378041C165220095 @default.
- W2469378041 hasConceptScore W2469378041C203014093 @default.
- W2469378041 hasConceptScore W2469378041C2777702733 @default.
- W2469378041 hasConceptScore W2469378041C2779306644 @default.
- W2469378041 hasConceptScore W2469378041C2780091579 @default.
- W2469378041 hasConceptScore W2469378041C28328180 @default.
- W2469378041 hasConceptScore W2469378041C2908554679 @default.
- W2469378041 hasConceptScore W2469378041C2911091166 @default.
- W2469378041 hasConceptScore W2469378041C2993713153 @default.
- W2469378041 hasConceptScore W2469378041C71924100 @default.
- W2469378041 hasConceptScore W2469378041C86803240 @default.
- W2469378041 hasConceptScore W2469378041C95444343 @default.
- W2469378041 hasIssue "2" @default.
- W2469378041 hasLocation W24693780411 @default.
- W2469378041 hasOpenAccess W2469378041 @default.
- W2469378041 hasPrimaryLocation W24693780411 @default.
- W2469378041 hasRelatedWork W2014360173 @default.
- W2469378041 hasRelatedWork W2032080984 @default.
- W2469378041 hasRelatedWork W2063352315 @default.
- W2469378041 hasRelatedWork W2078349724 @default.
- W2469378041 hasRelatedWork W2149350546 @default.
- W2469378041 hasRelatedWork W2316611054 @default.
- W2469378041 hasRelatedWork W2469378041 @default.
- W2469378041 hasRelatedWork W3029884639 @default.
- W2469378041 hasRelatedWork W3029980750 @default.
- W2469378041 hasRelatedWork W3126427020 @default.
- W2469378041 hasVolume "1" @default.
- W2469378041 isParatext "false" @default.
- W2469378041 isRetracted "false" @default.
- W2469378041 magId "2469378041" @default.
- W2469378041 workType "article" @default.