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• W2469480657 abstract "Event Abstract Back to Event NEURAL SOURCES FROM RESTING STATE EEG OSCILLATIONS IN ANGELMAN SYNDROME Carlos E. Cevallos1, Karine Pelc2, Bernard Dan1, 2, 3 and Guy Cheron4* 1 Universite Libre de Bruxelles, Laboratory of Neurophysiology and Movement Biomechanics, Belgium 2 Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles (ULB), Belgium 3 Inkendaal Rehabilitation Hospital, Belgium 4 Laboratory of Electrophysiology, Université Mons-Hainaut, Belgium Angelman syndrome (AS) is a neurodevelopmental genetic disease due to deficient UBE3A expression. We recorded and analyzed high density electroencephalogram (128 electrodes) by signal averaging and EEG inverse solution model estimation in 6 children with AS (aged 2-5) while in a default-mode (resting state). We found a consistent theta oscillation (5Hz) originating in somatosensory associative cortex (BA7) that could be explained by the contribution of the hippocampal network able to produce theta oscillation on the cortical mantle. We hope this new approach can be used to better understand the origin of the emergence of recurrent theta oscillations in AS patients. Résumé en Français: Titre: Enregistrement de l’activité cérébrale des patients souffrant du syndrome d’Angelman Le syndrome d’Angelman est une affection génétique qui perturbe le développement du cerveau menant à un retard mental sévère et des troubles de la motricité et de l’équilibre. Nous nous intéressons à l’activité électrique du cerveau chez les enfants atteints de ce syndrome. Cette activité est enregistrée grâce à l’électroencéphalographie qui permet de détecter les modifications de connexions entre les différentes zones du cerveau au repos et lors de tâches cognitives. Une meilleure compréhension du fonctionnement du cerveau de ces enfants pourrait permettre de mieux les stimuler afin d’améliorer leur condition. Samenvatting in het Nederlands: Titel: Het registreren van hersenactiviteit bij patiënten die lijden aan het syndroom van Angelman. Het syndroom van Angelman is een genetische aandoening die de ontwikkeling van de hersenen stoort, wat leidt tot mentale achterstand en een storing van de motoriek en het evenwicht. Wij interesseerden ons voor de elektrische activiteit van de hersenen bij kinderen die aan deze ziekte lijden. Deze activiteit wordt geregistreerd met een elektro-encefalografie die toelaat vast te stellen of er veranderingen optreden in de verbindingen tussen de diverse hersenzones, bij rust en tijdens het uitoefenen van cognitieve taken. Een beter begrip van het functioneren van de hersenen bij deze kinderen zou toelaten hen te stimuleren, en hun toestand te verbeteren. Keywords: Angelman Syndrome, EEG, oscillations, synchrony, neural networks, Epilepsy, source localization, Cortex Conference: 6th Belgian Brain Congress, MONS, Belgium, 8 Oct - 8 Oct, 2016. Presentation Type: Poster Presentation Topic: Brain and brain diseases: between heredity and environment Citation: Cevallos CE, Pelc K, Dan B and Cheron G (2016). NEURAL SOURCES FROM RESTING STATE EEG OSCILLATIONS IN ANGELMAN SYNDROME. Conference Abstract: 6th Belgian Brain Congress. doi: 10.3389/conf.fnagi.2016.03.00041 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jun 2016; Published Online: 05 Jul 2016. * Correspondence: Prof. Guy Cheron, Laboratory of Electrophysiology, Université Mons-Hainaut, Brussels, Belgium, guy.cheron@ulb.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract Supplemental Data The Authors in Frontiers Carlos E Cevallos Karine Pelc Bernard Dan Guy Cheron Google Carlos E Cevallos Karine Pelc Bernard Dan Guy Cheron Google Scholar Carlos E Cevallos Karine Pelc Bernard Dan Guy Cheron PubMed Carlos E Cevallos Karine Pelc Bernard Dan Guy Cheron Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2469480657 title "NEURAL SOURCES FROM RESTING STATE EEG OSCILLATIONS IN ANGELMAN SYNDROME" @default.
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