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- W2469740310 abstract "SummaryFour patients with multiple myeloma were treated once with 0.1 mg/kg vindesine in 24-h infusion monotherapy. Prior to and after therapy, immunoglobulin levels in the serum were measured with a laser nephelometer, usually at 24-h intervals. Immediately after administration of vindesine, increased paraprotein serum level was found in each patient. In three cases initial value of the paraprotein serum level was reached already after 3-7 days. Only in one case was the paraprotein serum level below the initial value in the 2nd week after vindesine administration. The increased paraprotein level in the early phase following administration of vindesine is interpreted as a liberation of monoclonal immunoglobulins from reversibly or irreversibly damaged plasma cells. Possibly, the measurement of the paraprotein serum level during the early phase following administration of certain chemotherapeutic agents may serve as an additional parameter for the evaluation of their effect in the treatment of multiple myeloma." @default.
- W2469740310 created "2016-07-22" @default.
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- W2469740310 date "1981-01-01" @default.
- W2469740310 modified "2023-09-27" @default.
- W2469740310 title "Multiple Myeloma: Paraprotein Serum Levels before and after Vindesine Therapy" @default.
- W2469740310 doi "https://doi.org/10.1159/000428645" @default.
- W2469740310 hasPublicationYear "1981" @default.
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