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• W2469778051 abstract "Throughout childhood, developing adequate muscle function is important for performing activities of daily living. We showed (Dougherty et al., J Pediatr Hematol Oncol, 2011) body size adjusted maximal muscle strength (accessed by handgrip dynamometer) and peak power (force plate) were reduced in children with type SS sickle cell disease (SCD-SS) compared to healthy children. However, no study in this population assessed if muscle performance deficits persist using a more functional measure, muscle torque (force applied over a distance causing rotation about a fulcrum). PURPOSE: To compare plantar flexor strength, adjusted for body size and composition, in 5 to 20 yr old African-American children with and without SCD-SS. METHODS: Anthropometry and DXA for body composition were measured and associated Z-scores generated. Plantar flexion isometric maximal voluntary contraction (MVC) torques of the left ankle at 2 angles (10, 20°) were assessed with the Biodex Multi-Joint System 3 Pro (Biodex Medical Systems, Inc, Shirley, NY). RESULTS: Twenty-one children with SCD-SS and 23 healthy control children did not differ by age (11 ± 1 vs. 10 ± 1 yrs), sex (male, female: 9, 12 vs. 13, 10) or maturation stage (Tanner 1, 2, 3, 4, 5: 10, 4, 3, 4, 0 vs. 11, 2, 5, 3. 2). Children with SCD-SS had significantly lower (all P < 0.05) height Z (-0.5 ± 0.3 vs. 0.4 ± 0.2), weight Z (-0.7 ± 0.3 vs. 0.8 ± 0.2), BMI Z (-0.6 ± 0.2 vs. 0.7 ± 0.2), arm circumference Z (-0.9 ± 0.3 vs. 0.8 ± 0.3), upper arm muscle area Z (-0.6 ± 0.3 vs. 1.0 ± 0.4), and whole body lean mass-for-height Z (-1.9 ± 0.2 vs. -0.9 ± 0.3). Unadjusted MVC torques were significantly lower in children with SCD-SS compared to healthy controls at each angle (10°: 27 ± 3 vs. 42 ± 5; 20°: 21 ± 3 vs. 34 ± 4 Nm; all P < 0.05). Group differences persisted when the highest MVC torques (at 10° angle) were adjusted for left leg length, lean and fat mass using multiple regression, together explaining 65% of the variance. CONCLUSIONS: After adjusting for growth and body composition deficits, plantar flexor strength is attenuated in children with SCD-SS compared to healthy children. This highlights the importance of improving growth status and body composition in children with SCD-SS and suggests additional factors contribute to decreased performance. Support: UL1TR000003, K12 (KL2RR024132), K23 (K23HL114637), CHOP Grants." @default.
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• W2469778051 date "2016-05-01" @default.
• W2469778051 modified "2023-10-14" @default.
• W2469778051 title "Attenuated Plantar Flexor Strength In Children With Type SS Sickle Cell Disease" @default.
• W2469778051 doi "https://doi.org/10.1249/01.mss.0000488070.81473.81" @default.
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