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- W2469832387 abstract "In this study, we review current knowledge regarding molecular pathways activation and their possible mechanisms in the perioperative period of coronary artery bypass surgery (CABG). We also highlight the role of off-pump CABG as a possible way to better understand these biological changes.We show that, after both on-pump and off-pump CABG, there is a marked and protracted activation of several molecular pathways indicating increased inflammatory status, haemostasis activation, as well as increased oxidative stress and unfavourable endothelial milieu. These changes persist for days and even weeks after surgery. Interestingly, a relatively limited number of these pathways show a more pronounced activation in case of cardiopulmonary bypass use, and these markers are mainly associated with oxidative stress activation; on the contrary, the vast majority of the pathways has a similar course both in on and off-pump procedures. Surgical stress accounts for more protracted and marked molecular pathway perturbations overall, being the effect of cardiopulmonary, if any, limited to the very early hours after surgery. The near future of the translational research in coronary bypass surgery is to develop therapeutic strategies aimed at reducing this response, that is largely unrelated to cardiopulmonary bypass use, in order to reduce perioperative complications and to speed up patients' recovery." @default.
- W2469832387 created "2016-07-22" @default.
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- W2469832387 date "2016-01-01" @default.
- W2469832387 modified "2023-10-17" @default.
- W2469832387 title "Molecular pathways activation in coronary artery bypass surgery" @default.
- W2469832387 cites W1552829599 @default.
- W2469832387 cites W1946152282 @default.
- W2469832387 cites W1964018514 @default.
- W2469832387 cites W1964769644 @default.
- W2469832387 cites W1968460690 @default.
- W2469832387 cites W1973352757 @default.
- W2469832387 cites W1975133375 @default.
- W2469832387 cites W1978076397 @default.
- W2469832387 cites W1989177493 @default.
- W2469832387 cites W1990158574 @default.
- W2469832387 cites W1990320030 @default.
- W2469832387 cites W1993564152 @default.
- W2469832387 cites W1996843068 @default.
- W2469832387 cites W2002504775 @default.
- W2469832387 cites W2003066717 @default.
- W2469832387 cites W2004045521 @default.
- W2469832387 cites W2005590339 @default.
- W2469832387 cites W2006551185 @default.
- W2469832387 cites W2007158657 @default.
- W2469832387 cites W2011895767 @default.
- W2469832387 cites W2014691397 @default.
- W2469832387 cites W2018345037 @default.
- W2469832387 cites W2023614561 @default.
- W2469832387 cites W2036786097 @default.
- W2469832387 cites W2043768128 @default.
- W2469832387 cites W2046559387 @default.
- W2469832387 cites W2049805605 @default.
- W2469832387 cites W2051304491 @default.
- W2469832387 cites W2054946683 @default.
- W2469832387 cites W2055006845 @default.
- W2469832387 cites W2061808238 @default.
- W2469832387 cites W2062275320 @default.
- W2469832387 cites W2064654231 @default.
- W2469832387 cites W2064790503 @default.
- W2469832387 cites W2067038207 @default.
- W2469832387 cites W2068987802 @default.
- W2469832387 cites W2069364701 @default.
- W2469832387 cites W2071170215 @default.
- W2469832387 cites W2071535279 @default.
- W2469832387 cites W2073466004 @default.
- W2469832387 cites W2083234630 @default.
- W2469832387 cites W2085232869 @default.
- W2469832387 cites W2087029426 @default.
- W2469832387 cites W2088407768 @default.
- W2469832387 cites W2095485506 @default.
- W2469832387 cites W2098507195 @default.
- W2469832387 cites W2098674170 @default.
- W2469832387 cites W2105279526 @default.
- W2469832387 cites W2107657427 @default.
- W2469832387 cites W2109056580 @default.
- W2469832387 cites W2109198654 @default.
- W2469832387 cites W2111247242 @default.
- W2469832387 cites W2111898162 @default.
- W2469832387 cites W2115575480 @default.
- W2469832387 cites W2117157607 @default.
- W2469832387 cites W2124032176 @default.
- W2469832387 cites W2124921706 @default.
- W2469832387 cites W2129324312 @default.
- W2469832387 cites W2134808810 @default.
- W2469832387 cites W2136474699 @default.
- W2469832387 cites W2143869751 @default.
- W2469832387 cites W2144145279 @default.
- W2469832387 cites W2145369334 @default.
- W2469832387 cites W2147556813 @default.
- W2469832387 cites W2155474120 @default.
- W2469832387 cites W2156930952 @default.
- W2469832387 cites W2163853618 @default.
- W2469832387 cites W2164213709 @default.
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- W2469832387 cites W2166127057 @default.
- W2469832387 cites W2166169466 @default.
- W2469832387 cites W2167394859 @default.
- W2469832387 cites W2168784876 @default.
- W2469832387 cites W2328632001 @default.
- W2469832387 cites W2418944039 @default.
- W2469832387 cites W31130990 @default.
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- W2469832387 doi "https://doi.org/10.2459/jcm.0000000000000293" @default.
- W2469832387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26418473" @default.
- W2469832387 hasPublicationYear "2016" @default.
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