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• W2469864999 abstract "After transplantation, CD4+ T cells are activated in response to allogeneic proteins of the major histocompatibility complex (MHC). These MHC proteins are recognized as processed MHC peptides bound to MHC class II molecules on the recipient’s antigen presenting cells. This so-called indirect pathway is essential in the process of allograft rejection and therefore seems to be ideal for the presentation of designed allo-MHC peptides with immunomodulative properties. Such peptides should prevent the activation of those T cells that are responsible for allograft rejection. We proved the practicability of this strategy in an experimental rat model. First, we analyzed different synthetic MHC class I peptides of the Wistar-Furth (WF, RT1u) rat strain for their ability to induce a T-cell alloresponse in Lewis (LEW, RT11) rats in order to identify the immunodominant wild type peptide. Second, based on the amino acid sequence of this peptide, analogues for T-cell modulation were designed.Eight 18-to-21-mer MHC class I peptides, representing nearly 80% of the extracellular region of the MHC class I molecules of WF rats, were proved for their possible immunogenicity in LEW rats. After 7 days the proliferation of peptide-specific T cells was determined in vitro [4]. Peptide P1 is immunodominant and induces Tcell proliferation of 20,000 cpm with a Th1 type specific cytokine profile (IL-2 and IFN-γ > 200 pg/ml). P1 differs in three amino acids from the corresponding region of MHC class I molecules of LEW rats. These amino acids were substituted sequentially and each analogue was tested for its immunogenicity. From the 6 possible analogues, peptide P1.5 reduced signiflcantly the strength of T cell response by more than 40%. Furthermore, these primed T cells, producing the immunoregulatory cytokines IL-4, IL-10, and IL-13 do not influence the rejection process.A strategy for inhibition of T-cell activation in an alloantigen specific manner may be useful in preventing the alloresponse against the allograft without suppressing the whole immune system. The present study shows the possibility of manipulating the T cell alloreactivity by the indirect pathway with synthetic MHC class I derived peptides. Furthermore, peptide analogues such as peptide P1.5 may be useful to suppress the T cell alloreactivity in order to prevent allograft rejection in an antigen-specific manner." @default.
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• W2469864999 date "2002-01-01" @default.
• W2469864999 modified "2023-09-26" @default.
• W2469864999 title "Alloantigenspezifische Modulation der Immunantwort nach Transplantation: Untersuchungen zur Immunogenität von MHC-Klasse-I Peptiden und ihren Varianten" @default.
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• W2469864999 doi "https://doi.org/10.1007/978-3-642-56158-0_67" @default.
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