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• W2469867897 abstract "Assembly and disassembly of adhesion struc- tures such as focal adhesions (FAs) and podosomes regulate cell adhesion and differentiation. On antigen-pre- senting dendritic cells (DCs), acquisition of a migratory and immunostimulatory phenotype depends on podosome dissolution by prostaglandin E2 (PGE2). Whereas the effects of physico-chemical and topographical cues have been extensively studied on FAs, little is known about how podosomes respond to these signals. Here, we show that, unlike for FAs, podosome formation is not controlled by substrate physico-chemical properties. We demonstrate that cell adhesion is the only prerequisite for podosome formation and that substrate availability dictates podosome density. Interestingly, we show that DCs sense 3-dimen- sional (3-D) geometry by aligning podosomes along the edges of 3-D micropatterned surfaces. Finally, whereas on a 2-dimensional (2-D) surface PGE2 causes a rapid increase in activated RhoA levels leading to fast podosome disso- lution, 3-D geometric cues prevent PGE2-mediated RhoA activation resulting in impaired podosome dissolution even after prolonged stimulation. Our findings indicate that 2-D Koen van den Dries and Suzanne F.G. van Helden contributed equally to this work." @default.
• W2469867897 created "2016-07-22" @default.
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• W2469867897 date "2012-01-01" @default.
• W2469867897 modified "2023-09-27" @default.
• W2469867897 title "Geometry sensing by dendritic cells dictates spatial organization and PGE 2 -induced dissolution of podosomes Koen van den DriesSuzanne F. G. van HeldenJoost te RietRuth Diez-Ahedo • Carlo ManzoMachteld M. OudFrank N. van LeeuwenRoland Brock • Maria F. Garcia-ParajoAlessandra CambiCarl G. Figdor" @default.
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