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- W2469873123 abstract "Objective To investigate esophageal high-resolution manometry （HRM） combined with 24-hour pH monitor in detecting endoscopy-negative chest pain of esophageal origin. Methods Test results of esophageal HRM combined with 24-hour pH monitor from 40 patients with recurring chest pain of esophageal origin were retrospectively analyzed. Results In 40 patients, 27 （67. 5% ） were diagnosed as gastroesophageal reflux disease with an average DeMeester scores at 18.3 ± 3.4, including 19 patients with esophageal body dismotility and 11 with reduced lower esophageal sphincter pressure （LESP） at a mean reduction of 5.7 mm Hg. There were 6 cases （ 15.0% ） of achalasia, in which 1 （2. 5% ） was type Ⅰ and 5 （ 12. 5% ） was type Ⅱ , with an average relaxation ratio of lower esophageal sphincter （RRLES） at （ 30. 1 ± 2. 3 ） %. There were 4 cases of diffuse esophageal spasm （DES）, with an average contraction frontal velocity （CFV） of 12. 3 ± 2. 4 cm.s^- 1 and abnormal contraction waves in esophageal body, spontaneous synchronous contraction waves were observed in 3 of 4 patients LESP increased in 1 patient with DES and remained normal in other 3. RRLES decreased in 2 cases with DES and remained normal in other 2. There were 2 cases （5. 0% ） of nutcracker esophagus, with an average distal contractile integral at 6745.5 ± 175.2 mm Hg.cm^-1 .s^-1 and an average CFV at4. 3 ±0. 4 cm.s^-1. There was 1 case （2. 5% ） with absence of esophageal peristalsis, with a low LESP at 2 mmHg and DeMeester scores at 38. 3. The patient was finally diagnosed as systemic sclerosis according to esophageal biopsy and other auxiliary examination. Conclusion HRM combined with 24-hour pH monitor is valuable in detecting endoscopy-negative chest pain of esophageal origin.Key words: Chest pain; Esophageal high-resolution manometry; Ambulatory esophageal pHmonitoring; Diagnosis" @default.
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- W2469873123 date "2013-04-20" @default.
- W2469873123 modified "2023-09-24" @default.
- W2469873123 title "Evaluation of esophageal high-resolution manometry combined with 24-hour pH monitor in detecting endoscopy-negative chest pain of esophageal origin" @default.
- W2469873123 doi "https://doi.org/10.3760/cma.j.issn.1007-5232.2013.04.009" @default.
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