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• W2469884346 abstract "Carbonaceous nanoparticles (CNP) represent a major constituent of urban particulate air pollution, and inhalation of high CNP levels has been described to trigger a pro-inflammatory response of the lung. While several studies identified specific particle characteristics driving respiratory toxicity of low-solubility and low-toxicity particles such as CNP, the major lung cell type, which initiates and drives that response, remains still uncertain. Since alveolar macrophages (AM) are known to effectively phagocytose inhaled particles and play a crucial role for the initiation of pulmonary inflammation caused by invading microbes, we aimed to determine their role for sterile stimuli such as CNP by profiling the primary alveolar cell compartments of the lung. We exposed C57BL/6 mice to 20 μg CNP by intratracheal instillation and comprehensively investigated the expression of the underlying mediators during a time span of 3 to 72 h in three different lung cell populations: CD45- (negative) structural cells, CD45+ (positive) leukocytes, and by BAL recovered cells.Bronchoalveolar lavage (BAL) analysis revealed an acute inflammatory response characterized by the most prominent culmination of neutrophil granulocytes from 12 to 24 h after instillation, which declined to basal levels by day 7. As early as 3 h after CNP exposure 50 % of the AM revealed particle laden. BAL concentrations and lung gene expression profiles of TNFα, and the neutrophil chemoattractants CXCL1,-2 and-5 preceded the neutrophil recruitment and showed highest levels after 12 h of CNP exposure, pointing to a significant activation of the inflammation-evoking lung cells at this point of time. AM, isolated from lungs 3 to 12 h after CNP instillation, however, did not show a pro-inflammatory signature. On the contrary, gene expression analysis of different lung cell populations isolated 12 h after CNP instillation revealed CD45-, mainly representing alveolar epithelial type II (ATII) cells as major producer of inflammatory CXCL cytokines. Particularly by CD45- cells expressed Cxcl5 proved to be the most abundant chemokine, being 12 h after CNP exposure 24 (±11) fold induced.Our data suggests that AM are noninvolved in the initiation of the inflammatory response. ATII cells, which induced highest CXCL levels early on, might in contrast be the driver of acute neutrophilic inflammation upon pulmonary CNP exposure." @default.
• W2469884346 created "2016-07-22" @default.
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• W2469884346 date "2015-12-01" @default.
• W2469884346 modified "2023-10-17" @default.
• W2469884346 title "No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice" @default.
• W2469884346 cites W1503487191 @default.
• W2469884346 cites W1524557269 @default.
• W2469884346 cites W1532126421 @default.
• W2469884346 cites W1894101376 @default.
• W2469884346 cites W1951764919 @default.
• W2469884346 cites W1966230298 @default.
• W2469884346 cites W1967270772 @default.
• W2469884346 cites W1967434989 @default.
• W2469884346 cites W1978075207 @default.
• W2469884346 cites W1981013578 @default.
• W2469884346 cites W1986453396 @default.
• W2469884346 cites W1990568312 @default.
• W2469884346 cites W1993436403 @default.
• W2469884346 cites W1997255681 @default.
• W2469884346 cites W1999641656 @default.
• W2469884346 cites W2001622142 @default.
• W2469884346 cites W2004730548 @default.
• W2469884346 cites W2006451106 @default.
• W2469884346 cites W2010518989 @default.
• W2469884346 cites W2011707607 @default.
• W2469884346 cites W2024481637 @default.
• W2469884346 cites W2026398980 @default.
• W2469884346 cites W2026644554 @default.
• W2469884346 cites W2031084334 @default.
• W2469884346 cites W2031148890 @default.
• W2469884346 cites W2032635216 @default.
• W2469884346 cites W2032778102 @default.
• W2469884346 cites W2034077981 @default.
• W2469884346 cites W2036857066 @default.
• W2469884346 cites W2054874479 @default.
• W2469884346 cites W2056495937 @default.
• W2469884346 cites W2060636525 @default.
• W2469884346 cites W2066769252 @default.
• W2469884346 cites W2070331619 @default.
• W2469884346 cites W2072823956 @default.
• W2469884346 cites W2074748185 @default.
• W2469884346 cites W2077822799 @default.
• W2469884346 cites W2079260788 @default.
• W2469884346 cites W2083317912 @default.
• W2469884346 cites W2094735775 @default.
• W2469884346 cites W2096996607 @default.
• W2469884346 cites W2099960347 @default.
• W2469884346 cites W2100750710 @default.
• W2469884346 cites W2102663974 @default.
• W2469884346 cites W2103752974 @default.
• W2469884346 cites W2104784243 @default.
• W2469884346 cites W2106811865 @default.
• W2469884346 cites W2108147515 @default.
• W2469884346 cites W2110507951 @default.
• W2469884346 cites W2113860483 @default.
• W2469884346 cites W2113861222 @default.
• W2469884346 cites W2119042712 @default.
• W2469884346 cites W2120579640 @default.
• W2469884346 cites W2124776482 @default.
• W2469884346 cites W2125890978 @default.
• W2469884346 cites W2129671134 @default.
• W2469884346 cites W2132965335 @default.
• W2469884346 cites W2133817540 @default.
• W2469884346 cites W2135674505 @default.
• W2469884346 cites W2137080464 @default.
• W2469884346 cites W2142266640 @default.
• W2469884346 cites W2145373691 @default.
• W2469884346 cites W2146653132 @default.
• W2469884346 cites W2149006857 @default.
• W2469884346 cites W2152341396 @default.
• W2469884346 cites W2153445432 @default.
• W2469884346 cites W2153962607 @default.
• W2469884346 cites W2155118487 @default.
• W2469884346 cites W2157101382 @default.
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• W2469884346 cites W2170559128 @default.
• W2469884346 doi "https://doi.org/10.1186/s12989-016-0144-6" @default.
• W2469884346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4915176" @default.
• W2469884346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27328634" @default.
• W2469884346 hasPublicationYear "2015" @default.
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