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- W2469920658 abstract "During mitosis, RNA polymerase II (Pol II) and many transcription factors dissociate from chromatin, and transcription ceases globally. Transcription is known to restart in bulk by telophase, but whether de novo transcription at the mitosis–G1 transition is in any way distinct from later in interphase remains unknown. We tracked Pol II occupancy genome-wide in mammalian cells progressing from mitosis through late G1. Unexpectedly, during the earliest rounds of transcription at the mitosis–G1 transition, ∼50% of active genes and distal enhancers exhibit a spike in transcription, exceeding levels observed later in G1 phase. Enhancer–promoter chromatin contacts are depleted during mitosis and restored rapidly upon G1 entry but do not spike. Of the chromatin-associated features examined, histone H3 Lys27 acetylation levels at individual loci in mitosis best predict the mitosis–G1 transcriptional spike. Single-molecule RNA imaging supports that the mitosis–G1 transcriptional spike can constitute the maximum transcriptional activity per DNA copy throughout the cell division cycle. The transcriptional spike occurs heterogeneously and propagates to cell-to-cell differences in mature mRNA expression. Our results raise the possibility that passage through the mitosis–G1 transition might predispose cells to diverge in gene expression states." @default.
- W2469920658 created "2016-07-22" @default.
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- W2469920658 date "2016-06-15" @default.
- W2469920658 modified "2023-10-12" @default.
- W2469920658 title "A hyperactive transcriptional state marks genome reactivation at the mitosis–G1 transition" @default.
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- W2469920658 cites W1667902255 @default.
- W2469920658 cites W1761395234 @default.
- W2469920658 cites W1822366055 @default.
- W2469920658 cites W1838501880 @default.
- W2469920658 cites W1879918309 @default.
- W2469920658 cites W1965854549 @default.
- W2469920658 cites W1974223852 @default.
- W2469920658 cites W1977635650 @default.
- W2469920658 cites W1980328649 @default.
- W2469920658 cites W1981593440 @default.
- W2469920658 cites W1981772689 @default.
- W2469920658 cites W1981995086 @default.
- W2469920658 cites W1982328581 @default.
- W2469920658 cites W1984540000 @default.
- W2469920658 cites W1985567721 @default.
- W2469920658 cites W1985706594 @default.
- W2469920658 cites W1988760117 @default.
- W2469920658 cites W1991101546 @default.
- W2469920658 cites W1997850825 @default.
- W2469920658 cites W2010510953 @default.
- W2469920658 cites W2016645003 @default.
- W2469920658 cites W2017050402 @default.
- W2469920658 cites W2023186182 @default.
- W2469920658 cites W2023455124 @default.
- W2469920658 cites W2024520070 @default.
- W2469920658 cites W2025192021 @default.
- W2469920658 cites W2025870792 @default.
- W2469920658 cites W2027225113 @default.
- W2469920658 cites W2034731985 @default.
- W2469920658 cites W2042896709 @default.
- W2469920658 cites W2046321916 @default.
- W2469920658 cites W2048169348 @default.
- W2469920658 cites W2056523061 @default.
- W2469920658 cites W2058144279 @default.
- W2469920658 cites W2063380020 @default.
- W2469920658 cites W2071146479 @default.
- W2469920658 cites W2073504534 @default.
- W2469920658 cites W2083087496 @default.
- W2469920658 cites W2085020901 @default.
- W2469920658 cites W2085319408 @default.
- W2469920658 cites W2086629747 @default.
- W2469920658 cites W2090788819 @default.
- W2469920658 cites W2092258256 @default.
- W2469920658 cites W2103354991 @default.
- W2469920658 cites W2105085478 @default.
- W2469920658 cites W2106014350 @default.
- W2469920658 cites W2106136726 @default.
- W2469920658 cites W2124985265 @default.
- W2469920658 cites W2126131856 @default.
- W2469920658 cites W2128531085 @default.
- W2469920658 cites W2128940246 @default.
- W2469920658 cites W2129303921 @default.
- W2469920658 cites W2131245700 @default.
- W2469920658 cites W2135478764 @default.
- W2469920658 cites W2139846889 @default.
- W2469920658 cites W2141688036 @default.
- W2469920658 cites W2148261329 @default.
- W2469920658 cites W2149007204 @default.
- W2469920658 cites W2150451971 @default.
- W2469920658 cites W2156821248 @default.
- W2469920658 cites W2159018531 @default.
- W2469920658 cites W2162856980 @default.
- W2469920658 cites W2167033852 @default.
- W2469920658 cites W2167244112 @default.
- W2469920658 cites W2171808845 @default.
- W2469920658 cites W2173155483 @default.
- W2469920658 cites W2253035633 @default.
- W2469920658 cites W2289395881 @default.
- W2469920658 cites W2290825831 @default.
- W2469920658 cites W2316894622 @default.
- W2469920658 cites W2407302299 @default.
- W2469920658 cites W2416689957 @default.
- W2469920658 cites W4234163107 @default.
- W2469920658 cites W4256266823 @default.
- W2469920658 doi "https://doi.org/10.1101/gad.280859.116" @default.
- W2469920658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4926865" @default.
- W2469920658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27340175" @default.
- W2469920658 hasPublicationYear "2016" @default.