FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2469968400> ?p ?o ?g. }

• W2469968400 endingPage "e0157786" @default.
• W2469968400 startingPage "e0157786" @default.
• W2469968400 abstract "The neurological manifestations of dengue disease are occurring with greater frequency, and currently, no information is available regarding the reasons for this phenomenon. Some viruses infect and/or alter the function of endothelial organs, which results in changes in cellular function, including permeability of the blood-brain barrier (BBB), which allows the entry of infected cells or free viral particles into the nervous system.In the present study, we standardized two in vitro models, a polarized monolayer of mouse brain endothelial cells (MBECs) and an organized co-culture containing MBECs and astrocytes. Using these cell models, we assessed whether DENV-4 or the neuro-adapted dengue virus (D4MB-6) variant infects cells or induces changes in the structure or function of the endothelial barrier.The results showed that MBECs, but not astrocytes, were susceptible to infection with both viruses, although the percentage of infected cells was higher when the neuro-adapted virus variant was used. In both culture systems, DENV infection changed the localization of the tight junction proteins Zonula occludens (ZO-1) and Claudin-1 (Cln1), and this process was associated with a decrease in transendothelial resistance, an increase in macromolecule permeability and an increase in the paracellular passing of free virus particles. MBEC infection led to transcriptional up-regulation of adhesion molecules (VCAM-1 and PECAM) and immune mediators (MCP-1 and TNF- α) that are associated with immune cell transmigration, mainly in D4MB-6-infected cells.These results indicate that DENV infection in MBECs altered the structure and function of the BBB and activated the endothelium, affecting its transcellular and paracellular permeability and favoring the passage of viruses and the transmigration of immune cells. This phenomenon can be harnessed for neurotropic and neurovirulent strains to infect and induce alterations in the CNS." @default.
• W2469968400 created "2016-07-22" @default.
• W2469968400 creator A5042296782 @default.
• W2469968400 creator A5073430498 @default.
• W2469968400 date "2016-06-23" @default.
• W2469968400 modified "2023-10-14" @default.
• W2469968400 title "In Vitro Infection with Dengue Virus Induces Changes in the Structure and Function of the Mouse Brain Endothelium" @default.
• W2469968400 cites W140646084 @default.
• W2469968400 cites W1589010135 @default.
• W2469968400 cites W1902114397 @default.
• W2469968400 cites W1967725380 @default.
• W2469968400 cites W1968754528 @default.
• W2469968400 cites W1976036131 @default.
• W2469968400 cites W1984594686 @default.
• W2469968400 cites W1988384513 @default.
• W2469968400 cites W1993308460 @default.
• W2469968400 cites W1995636137 @default.
• W2469968400 cites W1995815488 @default.
• W2469968400 cites W2005812405 @default.
• W2469968400 cites W2010303397 @default.
• W2469968400 cites W2014712282 @default.
• W2469968400 cites W2016747731 @default.
• W2469968400 cites W2023216155 @default.
• W2469968400 cites W2032171093 @default.
• W2469968400 cites W2033828724 @default.
• W2469968400 cites W2037931437 @default.
• W2469968400 cites W2040073120 @default.
• W2469968400 cites W2041691478 @default.
• W2469968400 cites W2046787808 @default.
• W2469968400 cites W2047950435 @default.
• W2469968400 cites W2055227287 @default.
• W2469968400 cites W2072292894 @default.
• W2469968400 cites W2088968901 @default.
• W2469968400 cites W2089529899 @default.
• W2469968400 cites W2099051954 @default.
• W2469968400 cites W2108244474 @default.
• W2469968400 cites W2108680508 @default.
• W2469968400 cites W2112517483 @default.
• W2469968400 cites W2120819703 @default.
• W2469968400 cites W2122797450 @default.
• W2469968400 cites W2128970995 @default.
• W2469968400 cites W2134717733 @default.
• W2469968400 cites W2139502131 @default.
• W2469968400 cites W2141988882 @default.
• W2469968400 cites W2144504108 @default.
• W2469968400 cites W2149084368 @default.
• W2469968400 cites W2153109968 @default.
• W2469968400 cites W2154886070 @default.
• W2469968400 cites W2156367313 @default.
• W2469968400 cites W2156667412 @default.
• W2469968400 cites W2159856735 @default.
• W2469968400 cites W2160152455 @default.
• W2469968400 cites W2171930202 @default.
• W2469968400 cites W2177862132 @default.
• W2469968400 cites W2218137326 @default.
• W2469968400 cites W2268121442 @default.
• W2469968400 cites W3036895338 @default.
• W2469968400 cites W307882310 @default.
• W2469968400 cites W579127631 @default.
• W2469968400 doi "https://doi.org/10.1371/journal.pone.0157786" @default.
• W2469968400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4919088" @default.
• W2469968400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27336851" @default.
• W2469968400 hasPublicationYear "2016" @default.
• W2469968400 type Work @default.
• W2469968400 sameAs 2469968400 @default.
• W2469968400 citedByCount "32" @default.
• W2469968400 countsByYear W24699684002017 @default.
• W2469968400 countsByYear W24699684002018 @default.
• W2469968400 countsByYear W24699684002019 @default.
• W2469968400 countsByYear W24699684002020 @default.
• W2469968400 countsByYear W24699684002021 @default.
• W2469968400 countsByYear W24699684002022 @default.
• W2469968400 countsByYear W24699684002023 @default.
• W2469968400 crossrefType "journal-article" @default.
• W2469968400 hasAuthorship W2469968400A5042296782 @default.
• W2469968400 hasAuthorship W2469968400A5073430498 @default.
• W2469968400 hasBestOaLocation W24699684001 @default.
• W2469968400 hasConcept C120882062 @default.
• W2469968400 hasConcept C123012128 @default.
• W2469968400 hasConcept C134018914 @default.
• W2469968400 hasConcept C159047783 @default.
• W2469968400 hasConcept C169760540 @default.
• W2469968400 hasConcept C177779419 @default.
• W2469968400 hasConcept C196594336 @default.
• W2469968400 hasConcept C202751555 @default.
• W2469968400 hasConcept C203014093 @default.
• W2469968400 hasConcept C2522874641 @default.
• W2469968400 hasConcept C2776992346 @default.
• W2469968400 hasConcept C2778402981 @default.
• W2469968400 hasConcept C2779635636 @default.
• W2469968400 hasConcept C41625074 @default.
• W2469968400 hasConcept C529278444 @default.
• W2469968400 hasConcept C533803919 @default.
• W2469968400 hasConcept C55493867 @default.
• W2469968400 hasConcept C60903277 @default.
• W2469968400 hasConcept C86803240 @default.
• W2469968400 hasConcept C8891405 @default.
• W2469968400 hasConcept C95444343 @default.

• next