FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2469980905> ?p ?o ?g. }

• W2469980905 endingPage "80362" @default.
• W2469980905 startingPage "80350" @default.
• W2469980905 abstract "// YongJoong Kim 1 , Min Seon Lee 1 , Hag Dong Kim 1 , Joon Kim 1 1 Laboratory of Biochemistry, Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea Correspondence to: Joon Kim, email: joonkim@korea.ac.kr Keywords: glycosylation, secretion, ribosomal protein S3, ribosome Received: February 16, 2015      Accepted: February 18, 2016      Published: June 22, 2016 ABSTRACT Ribosomal protein S3 (rpS3) is a 243 amino acid component of the 40S ribosomal small subunit. It has multiple roles in translation and extra-ribosomal functions like apoptosis and DNA repair. RpS3 is secreted only in cancer cell lines. Presently, mass spectrometry analysis revealed rpS3 to be glycosylated at the Asn165 residue. A point mutation at this residue decreased secretion of rpS3 in cancer cell lines. Secretion was also inhibited by the endoplasmic reticulum (ER)-Golgi transport inhibitor Brefeldin A and by Tunicamycin, an inhibitor of N-linked glycosylation. N-linked glycosylation of rpS3 was confirmed as necessary for rpS3 secretion into culture media via the ER-Golgi dependent pathway. RpS3 bound to Concanavalin A, a carbohydrate binding lectin protein, while treatment with peptide-N-glycosidase F shifted the secreted rpS3 to a lower molecular weight band. In addition, the N165G mutant of rpS3 displayed reduced secretion compared to the wild-type. An in vitro binding assay detected rpS3 homodimer formation via the N-terminal region (rpS3:1–85) and a middle region (rpS3:95–158). The results indicate that the Asn 165 residue of rpS3 is a critical site for N-linked glycosylation and passage through the ER-Golgi secretion pathway." @default.
• W2469980905 created "2016-07-22" @default.
• W2469980905 creator A5031054461 @default.
• W2469980905 creator A5036825274 @default.
• W2469980905 creator A5053638488 @default.
• W2469980905 creator A5088088777 @default.
• W2469980905 date "2016-06-22" @default.
• W2469980905 modified "2023-10-03" @default.
• W2469980905 title "Ribosomal protein S3 (rpS3) secreted from various cancer cells is N-linked glycosylated" @default.
• W2469980905 cites W1750974667 @default.
• W2469980905 cites W1940345635 @default.
• W2469980905 cites W1971265845 @default.
• W2469980905 cites W1998506335 @default.
• W2469980905 cites W2004125187 @default.
• W2469980905 cites W2012986282 @default.
• W2469980905 cites W2015726066 @default.
• W2469980905 cites W2018042261 @default.
• W2469980905 cites W2019577213 @default.
• W2469980905 cites W2022780353 @default.
• W2469980905 cites W2031249600 @default.
• W2469980905 cites W2035650904 @default.
• W2469980905 cites W2036462969 @default.
• W2469980905 cites W2048002994 @default.
• W2469980905 cites W2052007733 @default.
• W2469980905 cites W2059428912 @default.
• W2469980905 cites W2065635384 @default.
• W2469980905 cites W2069330409 @default.
• W2469980905 cites W2076826746 @default.
• W2469980905 cites W2077031177 @default.
• W2469980905 cites W2077204863 @default.
• W2469980905 cites W2078395459 @default.
• W2469980905 cites W2094897657 @default.
• W2469980905 cites W2095315166 @default.
• W2469980905 cites W2100241105 @default.
• W2469980905 cites W2105542185 @default.
• W2469980905 cites W2107134877 @default.
• W2469980905 cites W2114527359 @default.
• W2469980905 cites W2140266186 @default.
• W2469980905 cites W2164009656 @default.
• W2469980905 cites W2171196720 @default.
• W2469980905 cites W4236459937 @default.
• W2469980905 doi "https://doi.org/10.18632/oncotarget.10180" @default.
• W2469980905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5348324" @default.
• W2469980905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27384988" @default.
• W2469980905 hasPublicationYear "2016" @default.
• W2469980905 type Work @default.
• W2469980905 sameAs 2469980905 @default.
• W2469980905 citedByCount "14" @default.
• W2469980905 countsByYear W24699809052017 @default.
• W2469980905 countsByYear W24699809052019 @default.
• W2469980905 countsByYear W24699809052020 @default.
• W2469980905 countsByYear W24699809052021 @default.
• W2469980905 countsByYear W24699809052022 @default.
• W2469980905 countsByYear W24699809052023 @default.
• W2469980905 crossrefType "journal-article" @default.
• W2469980905 hasAuthorship W2469980905A5031054461 @default.
• W2469980905 hasAuthorship W2469980905A5036825274 @default.
• W2469980905 hasAuthorship W2469980905A5053638488 @default.
• W2469980905 hasAuthorship W2469980905A5088088777 @default.
• W2469980905 hasBestOaLocation W24699809051 @default.
• W2469980905 hasConcept C104317684 @default.
• W2469980905 hasConcept C119062480 @default.
• W2469980905 hasConcept C139447449 @default.
• W2469980905 hasConcept C153911025 @default.
• W2469980905 hasConcept C158617107 @default.
• W2469980905 hasConcept C185592680 @default.
• W2469980905 hasConcept C2777313579 @default.
• W2469980905 hasConcept C2777575526 @default.
• W2469980905 hasConcept C2781373781 @default.
• W2469980905 hasConcept C38062823 @default.
• W2469980905 hasConcept C55493867 @default.
• W2469980905 hasConcept C67705224 @default.
• W2469980905 hasConcept C86803240 @default.
• W2469980905 hasConcept C88478588 @default.
• W2469980905 hasConceptScore W2469980905C104317684 @default.
• W2469980905 hasConceptScore W2469980905C119062480 @default.
• W2469980905 hasConceptScore W2469980905C139447449 @default.
• W2469980905 hasConceptScore W2469980905C153911025 @default.
• W2469980905 hasConceptScore W2469980905C158617107 @default.
• W2469980905 hasConceptScore W2469980905C185592680 @default.
• W2469980905 hasConceptScore W2469980905C2777313579 @default.
• W2469980905 hasConceptScore W2469980905C2777575526 @default.
• W2469980905 hasConceptScore W2469980905C2781373781 @default.
• W2469980905 hasConceptScore W2469980905C38062823 @default.
• W2469980905 hasConceptScore W2469980905C55493867 @default.
• W2469980905 hasConceptScore W2469980905C67705224 @default.
• W2469980905 hasConceptScore W2469980905C86803240 @default.
• W2469980905 hasConceptScore W2469980905C88478588 @default.
• W2469980905 hasIssue "49" @default.
• W2469980905 hasLocation W24699809051 @default.
• W2469980905 hasLocation W24699809052 @default.
• W2469980905 hasLocation W24699809053 @default.
• W2469980905 hasLocation W24699809054 @default.
• W2469980905 hasOpenAccess W2469980905 @default.
• W2469980905 hasPrimaryLocation W24699809051 @default.
• W2469980905 hasRelatedWork W1561260712 @default.
• W2469980905 hasRelatedWork W1578081864 @default.
• W2469980905 hasRelatedWork W1589636116 @default.

• next