Matches in SemOpenAlex for { <https://semopenalex.org/work/W2470040983> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2470040983 endingPage "306" @default.
- W2470040983 startingPage "306" @default.
- W2470040983 abstract "Glucocorticoids (GCs) play an essential role in the maintenance of homeostasis and aberrations in the mechanisms which control their secretion and/or activity are strongly implicated in the pathogenesis of a number of common diseases including depression, hypertension, diabetes/obesity and immune/inflammatory disease. Annexin 1 (ANXA1), a protein mediator of GC action, is a key regulator of GC secretion, acting within the brain and pituitary gland to depress the release of the hormones which normally drive GC production. Its mode of action is unusual as it acts by a juxtacrine/paracrine mechanism and, following secondary processing, appears to interact with formyl peptide receptors (FPRs). Ligands for FPRs include bacterial and viral peptides, lipid mediators of the resolution of inflammation and peptides concerned with the pathogenesis of Alzheimer’s disease, suggesting a complex interaction between GCs and inflammatory mediators in the brain and pituitary gland. Early life events (e.g. stress) exert long-term effects on ANXA1 expression and function in adulthood. ANXA1 may thus contribute to the altered disease susceptibility linked to adverse events in perinatal life and to disease pathogenesis in adulthood." @default.
- W2470040983 created "2016-07-22" @default.
- W2470040983 creator A5003096777 @default.
- W2470040983 creator A5030517920 @default.
- W2470040983 creator A5030974804 @default.
- W2470040983 creator A5050880509 @default.
- W2470040983 creator A5055174868 @default.
- W2470040983 creator A5060397110 @default.
- W2470040983 date "2006-01-01" @default.
- W2470040983 modified "2023-09-23" @default.
- W2470040983 title "Annexin 1: a mediator of glucocorticoid action at the neuroendocrine-immune interface." @default.
- W2470040983 hasPublicationYear "2006" @default.
- W2470040983 type Work @default.
- W2470040983 sameAs 2470040983 @default.
- W2470040983 citedByCount "0" @default.
- W2470040983 crossrefType "journal-article" @default.
- W2470040983 hasAuthorship W2470040983A5003096777 @default.
- W2470040983 hasAuthorship W2470040983A5030517920 @default.
- W2470040983 hasAuthorship W2470040983A5030974804 @default.
- W2470040983 hasAuthorship W2470040983A5050880509 @default.
- W2470040983 hasAuthorship W2470040983A5055174868 @default.
- W2470040983 hasAuthorship W2470040983A5060397110 @default.
- W2470040983 hasConcept C126322002 @default.
- W2470040983 hasConcept C134018914 @default.
- W2470040983 hasConcept C203014093 @default.
- W2470040983 hasConcept C2107291 @default.
- W2470040983 hasConcept C2776914184 @default.
- W2470040983 hasConcept C2780942790 @default.
- W2470040983 hasConcept C553184892 @default.
- W2470040983 hasConcept C68246026 @default.
- W2470040983 hasConcept C71924100 @default.
- W2470040983 hasConcept C86803240 @default.
- W2470040983 hasConcept C88634738 @default.
- W2470040983 hasConcept C8891405 @default.
- W2470040983 hasConceptScore W2470040983C126322002 @default.
- W2470040983 hasConceptScore W2470040983C134018914 @default.
- W2470040983 hasConceptScore W2470040983C203014093 @default.
- W2470040983 hasConceptScore W2470040983C2107291 @default.
- W2470040983 hasConceptScore W2470040983C2776914184 @default.
- W2470040983 hasConceptScore W2470040983C2780942790 @default.
- W2470040983 hasConceptScore W2470040983C553184892 @default.
- W2470040983 hasConceptScore W2470040983C68246026 @default.
- W2470040983 hasConceptScore W2470040983C71924100 @default.
- W2470040983 hasConceptScore W2470040983C86803240 @default.
- W2470040983 hasConceptScore W2470040983C88634738 @default.
- W2470040983 hasConceptScore W2470040983C8891405 @default.
- W2470040983 hasLocation W24700409831 @default.
- W2470040983 hasOpenAccess W2470040983 @default.
- W2470040983 hasPrimaryLocation W24700409831 @default.
- W2470040983 hasRelatedWork W1126405772 @default.
- W2470040983 hasRelatedWork W1503993920 @default.
- W2470040983 hasRelatedWork W1515723568 @default.
- W2470040983 hasRelatedWork W1626281050 @default.
- W2470040983 hasRelatedWork W1904414649 @default.
- W2470040983 hasRelatedWork W2002460419 @default.
- W2470040983 hasRelatedWork W2020121765 @default.
- W2470040983 hasRelatedWork W2022662491 @default.
- W2470040983 hasRelatedWork W2025175138 @default.
- W2470040983 hasRelatedWork W2067917639 @default.
- W2470040983 hasRelatedWork W2072002199 @default.
- W2470040983 hasRelatedWork W2082258383 @default.
- W2470040983 hasRelatedWork W2096689446 @default.
- W2470040983 hasRelatedWork W2126006662 @default.
- W2470040983 hasRelatedWork W2160517494 @default.
- W2470040983 hasRelatedWork W2954497101 @default.
- W2470040983 hasRelatedWork W3144972939 @default.
- W2470040983 hasRelatedWork W3207122606 @default.
- W2470040983 hasRelatedWork W2183648444 @default.
- W2470040983 hasRelatedWork W2739199238 @default.
- W2470040983 hasVolume "27" @default.
- W2470040983 isParatext "false" @default.
- W2470040983 isRetracted "false" @default.
- W2470040983 magId "2470040983" @default.
- W2470040983 workType "article" @default.