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- W2470068657 abstract "Abstract Lambert–Eaton syndrome (LES) is a rare immune-mediated disorder characterized by proximal leg weakness, autonomic symptoms and hypoactive tendon reflexes. The paraneoplastic form is associated with small-cell lung cancer in 50-60% of cases, whereas the remaining cases are found in younger adults with a higher likelihood of coexisting autoimmune disease. The early recognition of LES is crucial for improving clinical outcomes but remains a major challenge. In this review, we analyze the clinical characteristics and diagnostic considerations in treating LES through a series of three case studies, one of which showed definitive response to pyridostigmine and corticosteroid combination therapy, followed by spontaneous remission. Patients were assessed by image-based screening, serological testing and electrophysiological evaluations, which included respiratory and autonomic testing. A better understanding of the common pitfalls in the clinical, serological and neurophysiologic diagnosis of LES through assessment of typical LES dysfunction throughout the nervous system should enable improved recognition and treatment of this syndrome." @default.
- W2470068657 created "2016-07-22" @default.
- W2470068657 creator A5055728164 @default.
- W2470068657 creator A5072346826 @default.
- W2470068657 date "2016-07-14" @default.
- W2470068657 modified "2023-10-14" @default.
- W2470068657 title "Review of the Diagnostic Challenges of Lambert–Eaton Syndrome Revealed Through Three Case Reports" @default.
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- W2470068657 doi "https://doi.org/10.1017/cjn.2016.268" @default.
- W2470068657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27412406" @default.
- W2470068657 hasPublicationYear "2016" @default.
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