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- W2470147424 abstract "Systemic sclerosis is a heterogeneous condition characterized by microvascular damage, dysregulation of the immune system, and progressive fibrosis affecting skin and internal organs. Currently, there are no approved disease-modifying therapies, and management mostly involves treatment of organ-specific complications. In recent years, major advances have greatly improved our understanding of the disease process, especially the molecular mechanisms by which fibrosis becomes self-sustaining. We discuss selected aspects of these mechanisms with a focus on those relevant to ongoing efforts to develop disease-modifying therapies. We also discuss advances in identification of patient subtypes, and selected examples of potential disease-modifying therapies in clinical development." @default.
- W2470147424 created "2016-07-22" @default.
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- W2470147424 date "2016-05-01" @default.
- W2470147424 modified "2023-10-02" @default.
- W2470147424 title "Emerging strategies for treatment of systemic sclerosis" @default.
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- W2470147424 doi "https://doi.org/10.5301/jsrd.5000207" @default.
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