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• W2470196071 abstract "Progress in therapeutics and biotechnologies leveraging new insights in our understanding of cancer biology and progression have had an underwhelming clinical significance thus far. A key challenge arising from the creation of nanomedicines consolidating multiple desirable functionalities into a ‘all-in-one’ platform is that the layering of functionalities into a single agent introduces novel complexities that significantly impede clinical translation. An alternative design approach seeks to exploit intrinsically multi-functional building block to assemble nanomedicines from the bottom-up, yielding agents with a multiplicity of radiologic, pharmacologic, and therapeutic properties derived from a single constituent. Herein are highlighted recent developments in the formulation, multi-modal imaging, and targeting of an exemplary ‘one-for-all’ nanomaterial — the Pyropheophorbide Porphysome — treated from a hitherto unexplored clinical design and development perspective." @default.
• W2470196071 created "2016-07-22" @default.
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• W2470196071 date "2016-08-01" @default.
• W2470196071 modified "2023-09-26" @default.
• W2470196071 title "Rethinking translational nanomedicine: insights from the ‘bottom-up’ design of the Porphysome for guiding the clinical development of imageable nanomaterials" @default.
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• W2470196071 doi "https://doi.org/10.1016/j.cbpa.2016.06.015" @default.
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