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- W2470226742 endingPage "354" @default.
- W2470226742 startingPage "321" @default.
- W2470226742 abstract "Phagocytosis is the mechanism whereby cells engulf large particles. This process has long been recognized as a critical component of the innate immune response, which constitutes the organism’s defense against microorganisms. In addition, phagocytic internalization of apoptotic cells or cell fragments plays important roles in tissue homeostasis and remodeling. Phagocytosis requires target interactions with receptors on the plasma membrane of the phagocytic cell. Integrins have been identified as important mediators of particle clearance, in addition to their well-established roles in cell adhesion, migration and mechanotransduction. Indeed, these ubiquitously expressed proteins impart phagocytic capacity to epithelial, endothelial and mesenchymal cell types. The importance of integrins in particle internalization is emphasized by the ability of microbial and viral pathogens to exploit their signaling pathways to invade host cells, and by the wide variety of disorders that arise from abnormalities in integrin-dependent phagocytic uptake." @default.
- W2470226742 created "2016-07-22" @default.
- W2470226742 creator A5042369001 @default.
- W2470226742 creator A5086029201 @default.
- W2470226742 date "2013-01-01" @default.
- W2470226742 modified "2023-10-13" @default.
- W2470226742 title "Integrins and Small GTPases as Modulators of Phagocytosis" @default.
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