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- W2470245511 abstract "ABSTRACT: The great part of the morbimortality associated with the colorretal surgery, is related with the anastomotic dehiscen ce.Experimental trials on the utility of tissue adhesives in the colonic anastomosis are controversial, as well as prospective randomizedclinical studies are absent. BioGlue® Surgical Adhesive(BSA) is a two-component surgical adhesive composed of purified bovineserum albumin and glutaraldehyde. The glutaraldehyde molecules covalently bond (cross-link) the BSA molecules to each otherand, upon application, to the tissue proteins at the repair site. The aim of this study is to evaluate the effectiveness of the BioGlue®in the prevention of the anastomotic colonic dehiscence in rats. Thirty male Wistar rats had been used. The colocolonic anastomosiswas confectioned with separate stitches with polypropylene 5-0 (group 1) and the application of the BioGlue® Surgical Adhesive(group 2). The formation and extension of the adhesions, the histological alterations and the rupture pressure had been evaluated.In the group 1, we have only 7% of mortality (01 animal), being evidenced in the autopsy, intestinal obstruction with major boweldistension. The mortality in group 2, on the other hand, was 67% (10 animals), being observed: bowel distension, anastomoticdehiscence and, in some situations, fecal peritonitis because of anastomotic total dehiscence. We concluded in the present stud y that,the use of BioGlue® Surgical Adhesive in colonic anastomosis in rats, is associated with an increase of the morbimortality incomparison with conventional suture which was statistically significant.Key words: Bioglue, colonic anastomosis, dehiscence." @default.
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- W2470245511 date "2007-01-01" @default.
- W2470245511 modified "2023-09-26" @default.
- W2470245511 title "Influência da Cola Bioglue na Deiscência de Anastomose Colônica. Estudo Experimental Influence of Bioglue Surgical Adhesive on colonic anastomosis dehiscence." @default.
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