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• W2470312249 abstract "We investigated if prostaglandins might regulate the increased choroidal endothelial (e) nitric oxide synthase (NOS) expression in the perinate. Prostaglandins, eNOS mRNA, immunoreactive protein and activity, and nitrite [stable metabolite of nitric oxide (NO)] production were markedly higher in newborn (1 day old) than juvenile (6–8 wk old) pig choroid. Treatment of isolated newborn choroids with the prostaglandin synthase inhibitor ibuprofen for 24 h reduced eNOS mRNA and nitrite production to values in juveniles. This effect was equally observed with the PGD 2 receptor (DP) blocker BW A868C and was prevented by cotreatment with PGD 2 but not other prostaglandins; similar observations were made on NOS activity in vivo. PGD 2 also increased eNOS expression on choroids of juveniles, and this effect was blocked by BW A868C. The manifestation of this upregulation of eNOS by PGD 2 on the control of choroidal vasomotor response was tested by using NO-dependent vasorelaxants, ACh, bradykinin (Bk), and substance P (SP). ACh-, Bk-, and SP-elicited choroidal vasorelaxation was greater in saline-treated newborn than juvenile pigs. Ibuprofen (24 h) decreased ACh-, Bk-, and SP-evoked vasorelaxation in newborns, whereas PGD 2 increased that in juveniles and prevented the ibuprofen-induced attenuated relaxation in newborns; infusion of N ω -monomethyl-l-arginine in choroids of those animals treated with PGD 2 reversed the augmented vasorelaxation to ACh, Bk, and SP. Finally, PGD 2 -induced upregulation of NOS in the perinate was also reflected by curtailed choroidal blood flow autoregulatory response to increased perfusion pressure. In conclusion, PGD 2 exhibits a major role in upregulating eNOS expression and activity in the choroid, which in turn results in greater NO-mediated vasorelaxation; a new mechanism for eNOS regulation via DP is hereby disclosed. The relationship between PGD 2 and eNOS in the developing subject provides an explanation for the interactive role of these two factors in the absent choroidal blood flow autoregulation in the perinate." @default.
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• W2470312249 date "2000-01-01" @default.
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• W2470312249 title "Regulation of endothelial nitric oxide synthase by PGD₂ in the developing choroid" @default.
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• W2470312249 doi "https://doi.org/10.1152/ajpheart.2000.278.1.h60" @default.
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