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• W2470377014 abstract "Linker histones are an integral component of chromatin but how these proteins promote assembly of chromatin fibers and higher order structures and regulate gene expression remains an open question. Using Förster resonance energy transfer (FRET) approaches we find that association of a linker histone with oligonucleosomal arrays induces condensation of the intrinsically disordered H1 CTD in a manner consistent with adoption of a defined fold or ensemble of folds in the bound state. However, H1 CTD structure when bound to nucleosomes in arrays is distinct from that induced upon H1 association with mononucleosomes or bare double stranded DNA. Moreover, the H1 CTD becomes more condensed upon condensation of extended nucleosome arrays to the contacting zig-zag form found in moderate salts, but does not detectably change during folding to fully compacted chromatin fibers. We provide evidence that linker DNA conformation is a key determinant of H1 CTD structure and that constraints imposed by neighboring nucleosomes cause linker DNAs to adopt distinct trajectories in oligonucleosomes compared to H1-bound mononucleosomes. Finally, inter-molecular FRET between H1s within fully condensed nucleosome arrays suggests a regular spatial arrangement for the H1 CTD within the 30 nm chromatin fiber." @default.
• W2470377014 created "2016-07-22" @default.
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• W2470377014 date "2016-06-30" @default.
• W2470377014 modified "2023-10-16" @default.
• W2470377014 title "Chromatin structure-dependent conformations of the H1 CTD" @default.
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• W2470377014 doi "https://doi.org/10.1093/nar/gkw586" @default.
• W2470377014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5100576" @default.
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• W2470377014 hasPublicationYear "2016" @default.
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