FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2470424349> ?p ?o ?g. }

• W2470424349 abstract "Gd-LC6-SH is a thiol-bearing DOTA complex of gadolinium designed to bind plasma albumin at the conserved Cys 34 site. The binding of Gd-LC6-SH shows sensitivity to the presence of competing thiols. We hypothesized that Gd-LC6-SH could provide magnetic resonance imaging (MRI) enhancement that is sensitive to tumor redox state and that the prolonged retention of albumin-bound Gd-LC6-SH in vivo can be exploited to identify a saturating dose above which the shortening of MRI longitudinal relaxation time (T 1) of tissue is insensitive to the injected gadolinium dose. In the Mia-PaCa-2 pancreatic tumor xenograft model in SCID mice, both the small-molecule Gd-DTPA-BMA and the macromolecule Galbumin MRI contrast agents produced dose-dependent decreases in tumor T 1 .B y contrast, the decreases in tumor T 1 provided by Gd-LC6-SH at 0.05 and 0.1 mmol/kg were not significantly different at longer times after injection. SCID mice bearing Mia-PaCa-2 or NCI-N87 tumor xenografts were treated with either the glutathione synthesis inhibitor buthionine sulfoximine or the thiol-oxidizing anticancer drug Imexon, respectively. In both models, there was a significantly greater increase in tumor R1 (=1/T 1) 60 minutes after injection of Gd-LC6-SH in drug-treated animals relative to saline-treated controls. In addition, Mercury Orange staining for nonprotein sulfhydryls was significantly decreased by drug treatment relative to controls in both tumor models. In summary, these studies show that thiol-bearing complexes of gadolinium such as Gd-LC6-SH can serve as redox-sensitive MRI contrast agents for detecting differences in tumor redox status and can be used to evaluate the effects of redox-active drugs." @default.
• W2470424349 created "2016-07-22" @default.
• W2470424349 creator A5011101496 @default.
• W2470424349 creator A5015106040 @default.
• W2470424349 creator A5042481525 @default.
• W2470424349 creator A5056259610 @default.
• W2470424349 creator A5060435181 @default.
• W2470424349 creator A5070130751 @default.
• W2470424349 date "2012-01-01" @default.
• W2470424349 modified "2023-09-27" @default.
• W2470424349 title "Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using" @default.
• W2470424349 cites W1528502383 @default.
• W2470424349 cites W1913419146 @default.
• W2470424349 cites W1967847250 @default.
• W2470424349 cites W1973870896 @default.
• W2470424349 cites W1976446646 @default.
• W2470424349 cites W1977296368 @default.
• W2470424349 cites W1983480912 @default.
• W2470424349 cites W1983636578 @default.
• W2470424349 cites W1995370236 @default.
• W2470424349 cites W1997188535 @default.
• W2470424349 cites W2001174028 @default.
• W2470424349 cites W2004743636 @default.
• W2470424349 cites W2007165774 @default.
• W2470424349 cites W2007255509 @default.
• W2470424349 cites W2014729064 @default.
• W2470424349 cites W2017121690 @default.
• W2470424349 cites W2018276670 @default.
• W2470424349 cites W2034489249 @default.
• W2470424349 cites W2036817332 @default.
• W2470424349 cites W2041149058 @default.
• W2470424349 cites W2041379917 @default.
• W2470424349 cites W2043311161 @default.
• W2470424349 cites W2052955020 @default.
• W2470424349 cites W2053928409 @default.
• W2470424349 cites W2058002482 @default.
• W2470424349 cites W2063087840 @default.
• W2470424349 cites W2064707851 @default.
• W2470424349 cites W2065590978 @default.
• W2470424349 cites W2070651271 @default.
• W2470424349 cites W2082465243 @default.
• W2470424349 cites W2086378628 @default.
• W2470424349 cites W2088895925 @default.
• W2470424349 cites W2115404190 @default.
• W2470424349 cites W2118403867 @default.
• W2470424349 cites W2129646875 @default.
• W2470424349 cites W2151356248 @default.
• W2470424349 cites W2160810259 @default.
• W2470424349 cites W2167874767 @default.
• W2470424349 cites W2394500320 @default.
• W2470424349 cites W2109672696 @default.
• W2470424349 hasPublicationYear "2012" @default.
• W2470424349 type Work @default.
• W2470424349 sameAs 2470424349 @default.
• W2470424349 citedByCount "0" @default.
• W2470424349 crossrefType "journal-article" @default.
• W2470424349 hasAuthorship W2470424349A5011101496 @default.
• W2470424349 hasAuthorship W2470424349A5015106040 @default.
• W2470424349 hasAuthorship W2470424349A5042481525 @default.
• W2470424349 hasAuthorship W2470424349A5056259610 @default.
• W2470424349 hasAuthorship W2470424349A5060435181 @default.
• W2470424349 hasAuthorship W2470424349A5070130751 @default.
• W2470424349 hasConcept C126838900 @default.
• W2470424349 hasConcept C143409427 @default.
• W2470424349 hasConcept C150903083 @default.
• W2470424349 hasConcept C178790620 @default.
• W2470424349 hasConcept C181199279 @default.
• W2470424349 hasConcept C185592680 @default.
• W2470424349 hasConcept C202751555 @default.
• W2470424349 hasConcept C207001950 @default.
• W2470424349 hasConcept C2777476445 @default.
• W2470424349 hasConcept C2777824588 @default.
• W2470424349 hasConcept C2781324293 @default.
• W2470424349 hasConcept C502942594 @default.
• W2470424349 hasConcept C538909803 @default.
• W2470424349 hasConcept C55493867 @default.
• W2470424349 hasConcept C557651011 @default.
• W2470424349 hasConcept C71924100 @default.
• W2470424349 hasConcept C86803240 @default.
• W2470424349 hasConceptScore W2470424349C126838900 @default.
• W2470424349 hasConceptScore W2470424349C143409427 @default.
• W2470424349 hasConceptScore W2470424349C150903083 @default.
• W2470424349 hasConceptScore W2470424349C178790620 @default.
• W2470424349 hasConceptScore W2470424349C181199279 @default.
• W2470424349 hasConceptScore W2470424349C185592680 @default.
• W2470424349 hasConceptScore W2470424349C202751555 @default.
• W2470424349 hasConceptScore W2470424349C207001950 @default.
• W2470424349 hasConceptScore W2470424349C2777476445 @default.
• W2470424349 hasConceptScore W2470424349C2777824588 @default.
• W2470424349 hasConceptScore W2470424349C2781324293 @default.
• W2470424349 hasConceptScore W2470424349C502942594 @default.
• W2470424349 hasConceptScore W2470424349C538909803 @default.
• W2470424349 hasConceptScore W2470424349C55493867 @default.
• W2470424349 hasConceptScore W2470424349C557651011 @default.
• W2470424349 hasConceptScore W2470424349C71924100 @default.
• W2470424349 hasConceptScore W2470424349C86803240 @default.
• W2470424349 hasLocation W24704243491 @default.
• W2470424349 hasOpenAccess W2470424349 @default.
• W2470424349 hasPrimaryLocation W24704243491 @default.
• W2470424349 hasRelatedWork W1506477577 @default.

• next