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• W2470441010 abstract "Background Elevated serum levels of asymmetric dimethylarginine (ADMA) are associated with endothelial dysfunction and atherogenesis. In patients with suspected coronary artery disease (CAD), we assessed the correlation of serum ADMA levels with extent and functional significance of coronary atherosclerosis. Methods We enrolled 281 patients with suspected CAD undergoing coronary angiogram. Angiographic CAD severity was evaluated by Bogaty score. In patients with angiographic evidence of at least one intermediate coronary stenosis (≥50% diameter stenosis), functional significance was assessed by fractional flow reserve (FFR). Blood samples were collected in all patients prior to coronary angiography for measurement of serum ADMA levels. Results We observed across tertiles of ADMA levels increasingly higher values of both Stenosis Score (2.25 ± 1.70 vs. 2.89 ± 1.99 vs. 2.95 ± 1.82, p = 0.016) and Extent Index (0.52 ± 0.32 vs. 0.61 ± 0.39 vs. 0.72 ± 0.47, p = 0.003). The association between ADMA levels and Extent Index remained significant after multivariate adjustment (p = 0.005). Patients with FFR ≤0.80 in at least one vessel (n = 113) had significantly higher ADMA levels compared with patients without functionally significant CAD (0.51 [0.43–0.64] vs. 0.46 [0.39–0.58] μmol/L, p = 0.005). Serum ADMA levels were independent predictors of abnormal FFR after adjustment for extent score (odds ratio 7.35, 95% confidence interval 1.05–56.76, p = 0.046). Conclusions Serum ADMA levels are independent predictors of coronary atherosclerosis extent and functional significance of CAD." @default.
• W2470441010 created "2016-07-22" @default.
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• W2470441010 date "2016-10-01" @default.
• W2470441010 modified "2023-09-29" @default.
• W2470441010 title "Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis" @default.
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• W2470441010 doi "https://doi.org/10.1016/j.ijcard.2016.06.254" @default.
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