FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2470536191> ?p ?o ?g. }

• W2470536191 abstract "The intracellular serine amidase, fatty acid amide hydrolase (FAAH), degrades a heterogeneous family of lipid-derived bioactive molecules that include amides of long-chain fatty acids with taurine [N-acyl-taurines (NATs)]. The physiological functions of the NATs are unknown. Here we show that genetic or pharmacological disruption of FAAH activity accelerates skin wound healing in mice and stimulates motogenesis of human keratinocytes and differentiation of human fibroblasts in primary cultures. Using untargeted and targeted lipidomics strategies, we identify two long-chain saturated NATs-N-tetracosanoyl-taurine [NAT(24:0)] and N-eicosanoyl-taurine [NAT(20:0)]-as primary substrates for FAAH in mouse skin, and show that the levels of these substances sharply decrease at the margins of a freshly inflicted wound to increase again as healing begins. Additionally, we demonstrate that local administration of synthetic NATs accelerates wound closure in mice and stimulates repair-associated responses in primary cultures of human keratinocytes and fibroblasts, through a mechanism that involves tyrosine phosphorylation of the epidermal growth factor receptor and an increase in intracellular calcium levels, under the permissive control of transient receptor potential vanilloid-1 receptors. The results point to FAAH-regulated NAT signaling as an unprecedented lipid-based mechanism of wound-healing control in mammalian skin, which might be targeted for chronic wound therapy." @default.
• W2470536191 created "2016-07-22" @default.
• W2470536191 creator A5009432809 @default.
• W2470536191 creator A5011179197 @default.
• W2470536191 creator A5020978349 @default.
• W2470536191 creator A5027181703 @default.
• W2470536191 creator A5031213755 @default.
• W2470536191 creator A5050965877 @default.
• W2470536191 creator A5060871332 @default.
• W2470536191 creator A5073242624 @default.
• W2470536191 creator A5089222886 @default.
• W2470536191 creator A5089764806 @default.
• W2470536191 date "2016-07-13" @default.
• W2470536191 modified "2023-10-16" @default.
• W2470536191 title "Endogenous <i>N</i> -acyl taurines regulate skin wound healing" @default.
• W2470536191 cites W1498357119 @default.
• W2470536191 cites W1505584712 @default.
• W2470536191 cites W1871922144 @default.
• W2470536191 cites W1963484569 @default.
• W2470536191 cites W1969064400 @default.
• W2470536191 cites W1971140102 @default.
• W2470536191 cites W1988165548 @default.
• W2470536191 cites W1988458770 @default.
• W2470536191 cites W1989021197 @default.
• W2470536191 cites W1989073099 @default.
• W2470536191 cites W2002535987 @default.
• W2470536191 cites W2008330541 @default.
• W2470536191 cites W2013537969 @default.
• W2470536191 cites W2013744734 @default.
• W2470536191 cites W2016951305 @default.
• W2470536191 cites W2020712150 @default.
• W2470536191 cites W2024611006 @default.
• W2470536191 cites W2026469610 @default.
• W2470536191 cites W2029497643 @default.
• W2470536191 cites W2032991676 @default.
• W2470536191 cites W2033772252 @default.
• W2470536191 cites W2037216246 @default.
• W2470536191 cites W2041980085 @default.
• W2470536191 cites W2046965677 @default.
• W2470536191 cites W2056681493 @default.
• W2470536191 cites W2057095795 @default.
• W2470536191 cites W2064380271 @default.
• W2470536191 cites W2065679828 @default.
• W2470536191 cites W2070995184 @default.
• W2470536191 cites W2072968157 @default.
• W2470536191 cites W2084375915 @default.
• W2470536191 cites W2086104636 @default.
• W2470536191 cites W2087526704 @default.
• W2470536191 cites W2092870606 @default.
• W2470536191 cites W2093340356 @default.
• W2470536191 cites W2095720174 @default.
• W2470536191 cites W2100592123 @default.
• W2470536191 cites W2106038133 @default.
• W2470536191 cites W2107961403 @default.
• W2470536191 cites W2110722372 @default.
• W2470536191 cites W2112006376 @default.
• W2470536191 cites W2114131246 @default.
• W2470536191 cites W2122248959 @default.
• W2470536191 cites W2123766496 @default.
• W2470536191 cites W2127903487 @default.
• W2470536191 cites W2131589396 @default.
• W2470536191 cites W2139846209 @default.
• W2470536191 cites W2143684129 @default.
• W2470536191 cites W2148767345 @default.
• W2470536191 cites W2150503227 @default.
• W2470536191 cites W2152311269 @default.
• W2470536191 cites W2157587499 @default.
• W2470536191 cites W2163351284 @default.
• W2470536191 cites W2165128851 @default.
• W2470536191 cites W2169838204 @default.
• W2470536191 cites W2170617040 @default.
• W2470536191 cites W2174180101 @default.
• W2470536191 cites W2300552860 @default.
• W2470536191 cites W2325727928 @default.
• W2470536191 cites W4241363254 @default.
• W2470536191 doi "https://doi.org/10.1073/pnas.1605578113" @default.
• W2470536191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4968764" @default.
• W2470536191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27412859" @default.
• W2470536191 hasPublicationYear "2016" @default.
• W2470536191 type Work @default.
• W2470536191 sameAs 2470536191 @default.
• W2470536191 citedByCount "35" @default.
• W2470536191 countsByYear W24705361912017 @default.
• W2470536191 countsByYear W24705361912018 @default.
• W2470536191 countsByYear W24705361912019 @default.
• W2470536191 countsByYear W24705361912020 @default.
• W2470536191 countsByYear W24705361912021 @default.
• W2470536191 countsByYear W24705361912022 @default.
• W2470536191 countsByYear W24705361912023 @default.
• W2470536191 crossrefType "journal-article" @default.
• W2470536191 hasAuthorship W2470536191A5009432809 @default.
• W2470536191 hasAuthorship W2470536191A5011179197 @default.
• W2470536191 hasAuthorship W2470536191A5020978349 @default.
• W2470536191 hasAuthorship W2470536191A5027181703 @default.
• W2470536191 hasAuthorship W2470536191A5031213755 @default.
• W2470536191 hasAuthorship W2470536191A5050965877 @default.
• W2470536191 hasAuthorship W2470536191A5060871332 @default.
• W2470536191 hasAuthorship W2470536191A5073242624 @default.
• W2470536191 hasAuthorship W2470536191A5089222886 @default.
• W2470536191 hasAuthorship W2470536191A5089764806 @default.

• next