Matches in SemOpenAlex for { <https://semopenalex.org/work/W2470568593> ?p ?o ?g. }
- W2470568593 abstract "Abstract Background Environmental stress affects the gut with dysmotility being a common consequence. Although a variety of microbes or molecules may prevent the dysmotility, none reverse the dysmotility. Methods We have used a 1 hour restraint stress mouse model to test for treatment effects of the neuroactive microbe, L. rhamnosus JB ‐1 ™ . Motility of fluid‐filled ex vivo gut segments in a perfusion organ bath was recorded by video and migrating motor complexes measured using spatiotemporal maps of diameter changes. Key Results Stress reduced jejunal and increased colonic propagating contractile cluster velocities and frequencies, while increasing contraction amplitudes for both. Luminal application of 10E8 cfu/mL JB ‐1 restored motor complex variables to unstressed levels within minutes of application. L. salivarius or Na.acetate had no treatment effects, while Na.butyrate partially reversed stress effects on colonic frequency and amplitude. Na.propionate reversed the stress effects for jejunum and colon except on jejunal amplitude. Conclusions & Inferences Our findings demonstrate, for the first time, a potential for certain beneficial microbes as treatment of stress‐induced intestinal dysmotility and that the mechanism for restoration of function occurs within the intestine via a rapid drug‐like action on the enteric nervous system." @default.
- W2470568593 created "2016-07-22" @default.
- W2470568593 creator A5004547333 @default.
- W2470568593 creator A5004895028 @default.
- W2470568593 creator A5010227537 @default.
- W2470568593 creator A5011971421 @default.
- W2470568593 creator A5025400360 @default.
- W2470568593 creator A5028347325 @default.
- W2470568593 creator A5028689323 @default.
- W2470568593 creator A5042063827 @default.
- W2470568593 creator A5060472622 @default.
- W2470568593 creator A5068329202 @default.
- W2470568593 creator A5075224435 @default.
- W2470568593 creator A5077301338 @default.
- W2470568593 creator A5081608291 @default.
- W2470568593 date "2016-07-06" @default.
- W2470568593 modified "2023-10-02" @default.
- W2470568593 title "<i>Lactobacillus rhamnosus</i>strain JB-1 reverses restraint stress-induced gut dysmotility" @default.
- W2470568593 cites W1934624334 @default.
- W2470568593 cites W1963530167 @default.
- W2470568593 cites W1968294128 @default.
- W2470568593 cites W1971641444 @default.
- W2470568593 cites W1972978634 @default.
- W2470568593 cites W1991772933 @default.
- W2470568593 cites W1995738249 @default.
- W2470568593 cites W1997571842 @default.
- W2470568593 cites W2002714430 @default.
- W2470568593 cites W2005534705 @default.
- W2470568593 cites W2006111974 @default.
- W2470568593 cites W2007935766 @default.
- W2470568593 cites W2009570194 @default.
- W2470568593 cites W2015994586 @default.
- W2470568593 cites W2023123778 @default.
- W2470568593 cites W2026926998 @default.
- W2470568593 cites W2034283231 @default.
- W2470568593 cites W2037009266 @default.
- W2470568593 cites W2039876000 @default.
- W2470568593 cites W2040475478 @default.
- W2470568593 cites W2040556005 @default.
- W2470568593 cites W2050519562 @default.
- W2470568593 cites W2052413517 @default.
- W2470568593 cites W2052547316 @default.
- W2470568593 cites W2080420967 @default.
- W2470568593 cites W2080830627 @default.
- W2470568593 cites W2083861291 @default.
- W2470568593 cites W2084399870 @default.
- W2470568593 cites W2084736890 @default.
- W2470568593 cites W2085567794 @default.
- W2470568593 cites W2087418736 @default.
- W2470568593 cites W2092654375 @default.
- W2470568593 cites W2093946239 @default.
- W2470568593 cites W2104319202 @default.
- W2470568593 cites W2112418861 @default.
- W2470568593 cites W2113822705 @default.
- W2470568593 cites W2122219120 @default.
- W2470568593 cites W2125894152 @default.
- W2470568593 cites W2137070227 @default.
- W2470568593 cites W2137395223 @default.
- W2470568593 cites W2139493081 @default.
- W2470568593 cites W2140717491 @default.
- W2470568593 cites W2149074973 @default.
- W2470568593 cites W2161753896 @default.
- W2470568593 cites W2164342861 @default.
- W2470568593 cites W2169050068 @default.
- W2470568593 cites W2171931264 @default.
- W2470568593 cites W2173009788 @default.
- W2470568593 cites W2180879622 @default.
- W2470568593 cites W2273595760 @default.
- W2470568593 cites W4229679860 @default.
- W2470568593 cites W4239923967 @default.
- W2470568593 cites W43571233 @default.
- W2470568593 doi "https://doi.org/10.1111/nmo.12903" @default.
- W2470568593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27381257" @default.
- W2470568593 hasPublicationYear "2016" @default.
- W2470568593 type Work @default.
- W2470568593 sameAs 2470568593 @default.
- W2470568593 citedByCount "25" @default.
- W2470568593 countsByYear W24705685932016 @default.
- W2470568593 countsByYear W24705685932017 @default.
- W2470568593 countsByYear W24705685932018 @default.
- W2470568593 countsByYear W24705685932019 @default.
- W2470568593 countsByYear W24705685932020 @default.
- W2470568593 countsByYear W24705685932021 @default.
- W2470568593 countsByYear W24705685932022 @default.
- W2470568593 countsByYear W24705685932023 @default.
- W2470568593 crossrefType "journal-article" @default.
- W2470568593 hasAuthorship W2470568593A5004547333 @default.
- W2470568593 hasAuthorship W2470568593A5004895028 @default.
- W2470568593 hasAuthorship W2470568593A5010227537 @default.
- W2470568593 hasAuthorship W2470568593A5011971421 @default.
- W2470568593 hasAuthorship W2470568593A5025400360 @default.
- W2470568593 hasAuthorship W2470568593A5028347325 @default.
- W2470568593 hasAuthorship W2470568593A5028689323 @default.
- W2470568593 hasAuthorship W2470568593A5042063827 @default.
- W2470568593 hasAuthorship W2470568593A5060472622 @default.
- W2470568593 hasAuthorship W2470568593A5068329202 @default.
- W2470568593 hasAuthorship W2470568593A5075224435 @default.
- W2470568593 hasAuthorship W2470568593A5077301338 @default.
- W2470568593 hasAuthorship W2470568593A5081608291 @default.
- W2470568593 hasConcept C100544194 @default.