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- W2470690794 abstract "The EGFR and B-Raf(V600E) dual inhibition is a promising strategy in treatment of colorectal cancer patients with B-Raf(V600E) mutation. Previously, compound 3 was designed and synthesized as a novel B-Raf(V600E) and EGFR dual inhibitor with highly potency in both kinase and cell based assay. Herein, a sensitive and rapid HPLC-MS/MS quantitative method was developed and validated for the further pharmacokinetic evaluation of compound 3 in rats." @default.
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- W2470690794 date "2016-09-01" @default.
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- W2470690794 title "Determination of a novel B-Raf V600E and EGFR dual inhibitor in rat plasma by HPLC–MS/MS and its application in a pharmacokinetic study" @default.
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- W2470690794 doi "https://doi.org/10.1016/j.jpba.2016.06.049" @default.
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