FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2470707961> ?p ?o ?g. }

• W2470707961 endingPage "315" @default.
• W2470707961 startingPage "307" @default.
• W2470707961 abstract "Glucokinase regulatory protein gene (GCKR) variant rs780092 is a novel genetic variant associated with serum triacylglycerol (TG) identified in a genome-wide association study in East Asians. We aimed to investigate associations of rs780092 with incident type 2 diabetes and dyslipidaemia, and the longitudinal changes in glucose and lipid levels.A community-based prospective cohort study was conducted at baseline in 2008, including 5,613 non-diabetic participants (37% male, mean age 57.6 years) with 5 years of follow-up. Blood glucose and lipid was measured at baseline and follow-up.Each rs780092 T-allele was associated with a 17% lower risk of incident type 2 diabetes (HR 0.83 [95% CI 0.73, 0.95]) and 36% higher risk of incident hypertriacylglycerolaemia (OR 1.36 [95% CI 1.08, 1.72]), after adjustment for baseline fasting glucose and TG and other confounders. The T-allele was associated with a 5 year increasing level of log10 TG (β ± SE, 0.01 ± 0.004, p = 0.005). Mediation analysis showed that both baseline TG and the 5 year increase in log10 TG were significant mediators in the associations of rs780092 with risk of diabetes. The risk of incident type 2 diabetes associated with 1 SD increase in total and LDL-cholesterol was 35% and 22% lower in TT carriers compared with CC carriers, respectively (both p for interaction ≤ 0.04).The GCKR rs780092 variant showed opposite-directional associations with type 2 diabetes and hypertriacylglycerolaemia in a Chinese population. Both baseline level and 5 year change in serum TG were mediators of the association between the genetic variant and type 2 diabetes." @default.
• W2470707961 created "2016-07-22" @default.
• W2470707961 creator A5001595399 @default.
• W2470707961 creator A5001940685 @default.
• W2470707961 creator A5012777958 @default.
• W2470707961 creator A5034127226 @default.
• W2470707961 creator A5035651363 @default.
• W2470707961 creator A5042865182 @default.
• W2470707961 creator A5058361837 @default.
• W2470707961 creator A5069611208 @default.
• W2470707961 creator A5072389210 @default.
• W2470707961 creator A5080107089 @default.
• W2470707961 creator A5081608997 @default.
• W2470707961 creator A5083595315 @default.
• W2470707961 creator A5090281350 @default.
• W2470707961 date "2015-10-29" @default.
• W2470707961 modified "2023-09-24" @default.
• W2470707961 title "Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis" @default.
• W2470707961 cites W2038702827 @default.
• W2470707961 cites W2048755332 @default.
• W2470707961 cites W2072399907 @default.
• W2470707961 cites W2073960217 @default.
• W2470707961 cites W2085649845 @default.
• W2470707961 cites W2086783863 @default.
• W2470707961 cites W2090392937 @default.
• W2470707961 cites W2096629131 @default.
• W2470707961 cites W2113052184 @default.
• W2470707961 cites W2115801316 @default.
• W2470707961 cites W2119913660 @default.
• W2470707961 cites W2121351699 @default.
• W2470707961 cites W2149891865 @default.
• W2470707961 cites W2156646969 @default.
• W2470707961 cites W2157803319 @default.
• W2470707961 cites W2159394707 @default.
• W2470707961 cites W2159422401 @default.
• W2470707961 cites W2607031541 @default.
• W2470707961 cites W4238251256 @default.
• W2470707961 doi "https://doi.org/10.1007/s00125-015-3788-0" @default.
• W2470707961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26515422" @default.
• W2470707961 hasPublicationYear "2015" @default.
• W2470707961 type Work @default.
• W2470707961 sameAs 2470707961 @default.
• W2470707961 citedByCount "9" @default.
• W2470707961 countsByYear W24707079612016 @default.
• W2470707961 countsByYear W24707079612017 @default.
• W2470707961 countsByYear W24707079612018 @default.
• W2470707961 countsByYear W24707079612021 @default.
• W2470707961 countsByYear W24707079612022 @default.
• W2470707961 countsByYear W24707079612023 @default.
• W2470707961 crossrefType "journal-article" @default.
• W2470707961 hasAuthorship W2470707961A5001595399 @default.
• W2470707961 hasAuthorship W2470707961A5001940685 @default.
• W2470707961 hasAuthorship W2470707961A5012777958 @default.
• W2470707961 hasAuthorship W2470707961A5034127226 @default.
• W2470707961 hasAuthorship W2470707961A5035651363 @default.
• W2470707961 hasAuthorship W2470707961A5042865182 @default.
• W2470707961 hasAuthorship W2470707961A5058361837 @default.
• W2470707961 hasAuthorship W2470707961A5069611208 @default.
• W2470707961 hasAuthorship W2470707961A5072389210 @default.
• W2470707961 hasAuthorship W2470707961A5080107089 @default.
• W2470707961 hasAuthorship W2470707961A5081608997 @default.
• W2470707961 hasAuthorship W2470707961A5083595315 @default.
• W2470707961 hasAuthorship W2470707961A5090281350 @default.
• W2470707961 hasBestOaLocation W24707079611 @default.
• W2470707961 hasConcept C104317684 @default.
• W2470707961 hasConcept C126322002 @default.
• W2470707961 hasConcept C134018914 @default.
• W2470707961 hasConcept C157410074 @default.
• W2470707961 hasConcept C180754005 @default.
• W2470707961 hasConcept C188816634 @default.
• W2470707961 hasConcept C201903717 @default.
• W2470707961 hasConcept C204452808 @default.
• W2470707961 hasConcept C2777180221 @default.
• W2470707961 hasConcept C2780578515 @default.
• W2470707961 hasConcept C2908647359 @default.
• W2470707961 hasConcept C37463918 @default.
• W2470707961 hasConcept C54355233 @default.
• W2470707961 hasConcept C555293320 @default.
• W2470707961 hasConcept C71924100 @default.
• W2470707961 hasConcept C72563966 @default.
• W2470707961 hasConcept C77350462 @default.
• W2470707961 hasConcept C86803240 @default.
• W2470707961 hasConcept C99454951 @default.
• W2470707961 hasConceptScore W2470707961C104317684 @default.
• W2470707961 hasConceptScore W2470707961C126322002 @default.
• W2470707961 hasConceptScore W2470707961C134018914 @default.
• W2470707961 hasConceptScore W2470707961C157410074 @default.
• W2470707961 hasConceptScore W2470707961C180754005 @default.
• W2470707961 hasConceptScore W2470707961C188816634 @default.
• W2470707961 hasConceptScore W2470707961C201903717 @default.
• W2470707961 hasConceptScore W2470707961C204452808 @default.
• W2470707961 hasConceptScore W2470707961C2777180221 @default.
• W2470707961 hasConceptScore W2470707961C2780578515 @default.
• W2470707961 hasConceptScore W2470707961C2908647359 @default.
• W2470707961 hasConceptScore W2470707961C37463918 @default.
• W2470707961 hasConceptScore W2470707961C54355233 @default.
• W2470707961 hasConceptScore W2470707961C555293320 @default.
• W2470707961 hasConceptScore W2470707961C71924100 @default.

• next