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• W2470848498 endingPage "e1006126" @default.
• W2470848498 startingPage "e1006126" @default.
• W2470848498 abstract "Many of the lipids found on the cuticles of insects function as pheromones and communicate information about age, sex, and reproductive status. In Drosophila, the composition of the information-rich lipid profile is dynamic and changes over the lifetime of an individual. However, the molecular basis of this change is not well understood. To identify genes that control cuticular lipid production in Drosophila, we performed a RNA interference screen and used Direct Analysis in Real Time and gas chromatography mass spectrometry to quantify changes in the chemical profiles. Twelve putative genes were identified whereby transcriptional silencing led to significant differences in cuticular lipid production. Amongst them, we characterized a gene which we name spidey, and which encodes a putative steroid dehydrogenase that has sex- and age-dependent effects on viability, pheromone production, and oenocyte survival. Transcriptional silencing or overexpression of spidey during embryonic development results in pupal lethality and significant changes in levels of the ecdysone metabolite 20-hydroxyecdysonic acid and 20-hydroxyecdysone. In contrast, inhibiting gene expression only during adulthood resulted in a striking loss of oenocyte cells and a concomitant reduction of cuticular hydrocarbons, desiccation resistance, and lifespan. Oenocyte loss and cuticular lipid levels were partially rescued by 20-hydroxyecdysone supplementation. Taken together, these results identify a novel regulator of pheromone synthesis and reveal that ecdysteroid signaling is essential for the maintenance of cuticular lipids and oenocytes throughout adulthood." @default.
• W2470848498 created "2016-07-22" @default.
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• W2470848498 date "2016-06-22" @default.
• W2470848498 modified "2023-10-12" @default.
• W2470848498 title "Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival" @default.
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• W2470848498 doi "https://doi.org/10.1371/journal.pgen.1006126" @default.
• W2470848498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4917198" @default.
• W2470848498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27333054" @default.
• W2470848498 hasPublicationYear "2016" @default.
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