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- W2470917246 abstract "Objective:To investigate the effect and the possible influencial mechanisms of hyperbaric oxygen(HBO) and 5-fluorouracil(5-FU) on the proliferation and metastasis in human nasopharyngeal carcinoma (NPC) CNE2Z cell line.Method:NPC CNE2Z cell line were divided into 4 groups randomly: group A: control group; group B:5-FU group;group C: HBO group; group D:5-FU and HBO group. The inhibition effect of proliferation in CNE2Z cells of all groups through 24 h、48 h and 72 h disposal was detected by MTT reduction assay; Transwell chamber assay was performed to determine the effect of HBO and(or) 5-FU on the metastasis of the CNE2Z cells; The MMP-9、VEGF expression in CNE2Z cells of all groups were detected by SP immunocytochemical stain and observe the expressed image by micro.Result:There were statistical difference on the inhibition effect of proliferation in C group and A group after 48 h and 72 h disposal(P0.01) and between A、B、C group and D group only after 48 h disposal(P0.05);There were not statistical difference on the effect of metastasis in C group and A group(P0.05) and between B、C group and D group(P0.05); Average optical of the MMP-9、VEGF expression were not statistically significant difference in C group and A group(P0.05) and between C group and D group(P0.05).Conclusion:Simple HBO disposal after 48 h and 72 h could inhibit the proliferation potential of NPC CNE2Z cell line, but the combination of HBO and 5-FU only after 48 h disposal could all the more inhibit the proliferation potential. Simple HBO disposal couldn't decrease the MMP-9 and VEGF high-expression and inhibit the metastasis potential in human NPC CNE2Z cell line, the combination of HBO and 5-FU disposal also couldn't further decreased the MMP-9 and VEGF high-expression and inhibited the metastasis potential." @default.
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- W2470917246 date "2010-05-01" @default.
- W2470917246 modified "2023-09-27" @default.
- W2470917246 title "[Effect of the combination of hyperbaric oxygen and 5-fluorouracil on the proliferation and metastasis of nasopharyngeal carcinoma CNE-2Z cell line]." @default.
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