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- W2471003709 abstract "Sylvia Agnes Sophia Wardropper became very skilled in the techniques and statistical interpretation of bioassays, in particular bioassays for estrogen. About this time, it became clear that in the amorphous unfractionated portion of adrenal extracts, a potent salt-retaining factor could consistently be demonstrated. Sylvia, working with James Tait and Helen Grundy, quickly simplified and improved the precision of this assay by using as an endpoint the 24Na/42K ratio in the urine of salt-loaded rats. This advance led naturally to the search for the chemical structure of electrocortin. Anthony Simpson and Tait had a long and productive career, dominating the aldosterone field for three decades. They were leaders in developing assays that could measure hormones in picomolar quantities. They, and the Lieberman-Siiteri-Gurpide group at Columbia, essentially developed the discipline of steroid dynamics and the compartment modeling of steroid metabolism." @default.
- W2471003709 created "2016-07-22" @default.
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- W2471003709 date "2016-02-12" @default.
- W2471003709 modified "2023-09-23" @default.
- W2471003709 title "Sylvia Agnes Sophia Tait (1917–2003)" @default.
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- W2471003709 doi "https://doi.org/10.1002/9781119205791.ch97" @default.
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