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• W2471031818 startingPage "1669" @default.
• W2471031818 abstract "Uncontrolled propagation of retrotransposons is potentially detrimental to host genome integrity. Therefore, cells have evolved surveillance mechanisms to restrict the mobility of these elements. In Schizosaccharomyces pombe the Tf2 LTR retrotransposons are transcriptionally silenced and are also clustered in the nucleus into structures termed Tf bodies. Here we describe the impact of silencing and clustering on the mobility of an endogenous Tf2 element. Deletion of genes such as set1(+) (histone H3 lysine 4 methyltransferase) or abp1(+) (CENP-B homolog) that both alleviate silencing and clustering, result in a corresponding increase in mobilization. Furthermore, expression of constitutively active Sre1, a transcriptional activator of Tf2 elements, also alleviates clustering and induces mobilization. In contrast, clustering is not disrupted by loss of the HIRA histone chaperone, despite high levels of expression, and in this background, mobilization frequency is only marginally increased. Thus, mutations that compromise transcriptional silencing but not Tf bodies are insufficient to drive mobilization. Furthermore, analyses of mutant alleles that separate the transcriptional repression and clustering functions of Set1 are consistent with control of Tf2 propagation via a combination of silencing and spatial organization. Our results indicate that host surveillance mechanisms operate at multiple levels to restrict Tf2 retrotransposon mobilization." @default.
• W2471031818 created "2016-07-22" @default.
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• W2471031818 date "2016-08-01" @default.
• W2471031818 modified "2023-10-14" @default.
• W2471031818 title "Restriction of Retrotransposon Mobilization in<i>Schizosaccharomyces pombe</i>by Transcriptional Silencing and Higher-Order Chromatin Organization" @default.
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• W2471031818 doi "https://doi.org/10.1534/genetics.116.189118" @default.
• W2471031818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4981269" @default.
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• W2471031818 hasPublicationYear "2016" @default.
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