FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471102126> ?p ?o ?g. }

• W2471102126 abstract "Recombinant Human Erythropoietin (EPO) replacement therapy effectively treats the chronic anaemic associated with end stage renal disease. However due to an increase in demand, a functional iron deficiency state may arise which is characterised by an inability to supply iron and subsequent EPO resistance. Indicators of iron status are potentially misleading in this situation. Red cell ferritin (RCFer) and reticulocyte indices may be more reliable measures of functional iron deficiency. We investigated, prospectively, the value of RCFer and reticulocyte indices to detect functional iron deficiency in 11 patients, 10 male and 1 female, mean age 51 years (ranges 20-74) commencing subcutaneous EPO therapy. All patients had received oral ferrous sulphate 600 mg, total dose, daily for 6 weeks prior to starting EPO. Study subjects had a mean aluminium of 1.1 mmol/L (28.9 μg/L) and parathyroid hormone (PTH) 109pg/L. Serum folate, vitamin B12 deficiencies and bleeding diathesis were excluded. Dialysis adequacy was maintained with a mean Kt/V (a measure of the amount of plasma cleared of urea divided by the urea distribution volume V) of 1.0 and urea reduction ratio of 64%. Haemoglobin rose from a mean value of 8.0-9.9g/dl (p < 0.01). There was an associated significant fall in both serum ferritin (SF) (205.5-62.88 μg/1, p< 0.01) and RCFer (19.96-10.8 ag/red cell, p < 0.001). After 96 days of EPO therapy, 18% of patients had a demonstrably reduced RCFer (< 7 ag/red cell) whilst none had a reduced SF (< 15 μg/L) and 75% had a transferrin saturation (TS) < 20%. Mean SF levels remained consistently above 50μg/L. There was no significant change in TS verifying its poor sensitivity as a marker of functional iron deficiency. Mean haemoglobin content of reticulocytes (CHr) and mean haemoglobin concentration of reticulocytes (CHCMr) fell (p < 0.001, p < 0.01 respectively) to levels suggesting iron deficiency at 3 months. These results suggest that RCFer and CHr may help detect the onset of functional iron deficiency in patients commencing EPO therapy despite oral iron. EPO therapy leads to a significant depletion of both erythroid and storage iron." @default.
• W2471102126 created "2016-07-22" @default.
• W2471102126 creator A5004586811 @default.
• W2471102126 creator A5039400508 @default.
• W2471102126 creator A5081395626 @default.
• W2471102126 creator A5086923762 @default.
• W2471102126 date "1998-01-01" @default.
• W2471102126 modified "2023-09-24" @default.
• W2471102126 title "Novel Haematological Parameters in Patients Receiving Recombinant Human Erythropoietin and Undergoing Haemodialysis" @default.
• W2471102126 cites W1569509366 @default.
• W2471102126 cites W1966790955 @default.
• W2471102126 cites W1983874550 @default.
• W2471102126 cites W1990097831 @default.
• W2471102126 cites W1994974557 @default.
• W2471102126 cites W2002958107 @default.
• W2471102126 cites W2026365609 @default.
• W2471102126 cites W2027903245 @default.
• W2471102126 cites W2045594803 @default.
• W2471102126 cites W2066413437 @default.
• W2471102126 cites W2067304757 @default.
• W2471102126 cites W2073935737 @default.
• W2471102126 cites W2083739752 @default.
• W2471102126 cites W2111867433 @default.
• W2471102126 cites W2123586641 @default.
• W2471102126 cites W2267189664 @default.
• W2471102126 cites W2312941466 @default.
• W2471102126 cites W2322941203 @default.
• W2471102126 cites W2332049197 @default.
• W2471102126 cites W2340124568 @default.
• W2471102126 cites W2435738983 @default.
• W2471102126 cites W4230424308 @default.
• W2471102126 cites W65479576 @default.
• W2471102126 doi "https://doi.org/10.1080/10245332.1998.11746380" @default.
• W2471102126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27416284" @default.
• W2471102126 hasPublicationYear "1998" @default.
• W2471102126 type Work @default.
• W2471102126 sameAs 2471102126 @default.
• W2471102126 citedByCount "2" @default.
• W2471102126 crossrefType "journal-article" @default.
• W2471102126 hasAuthorship W2471102126A5004586811 @default.
• W2471102126 hasAuthorship W2471102126A5039400508 @default.
• W2471102126 hasAuthorship W2471102126A5081395626 @default.
• W2471102126 hasAuthorship W2471102126A5086923762 @default.
• W2471102126 hasConcept C126322002 @default.
• W2471102126 hasConcept C134018914 @default.
• W2471102126 hasConcept C2777208419 @default.
• W2471102126 hasConcept C2777417653 @default.
• W2471102126 hasConcept C2778248108 @default.
• W2471102126 hasConcept C2778319317 @default.
• W2471102126 hasConcept C2778534260 @default.
• W2471102126 hasConcept C2779978075 @default.
• W2471102126 hasConcept C71924100 @default.
• W2471102126 hasConcept C78529466 @default.
• W2471102126 hasConcept C90924648 @default.
• W2471102126 hasConceptScore W2471102126C126322002 @default.
• W2471102126 hasConceptScore W2471102126C134018914 @default.
• W2471102126 hasConceptScore W2471102126C2777208419 @default.
• W2471102126 hasConceptScore W2471102126C2777417653 @default.
• W2471102126 hasConceptScore W2471102126C2778248108 @default.
• W2471102126 hasConceptScore W2471102126C2778319317 @default.
• W2471102126 hasConceptScore W2471102126C2778534260 @default.
• W2471102126 hasConceptScore W2471102126C2779978075 @default.
• W2471102126 hasConceptScore W2471102126C71924100 @default.
• W2471102126 hasConceptScore W2471102126C78529466 @default.
• W2471102126 hasConceptScore W2471102126C90924648 @default.
• W2471102126 hasLocation W24711021261 @default.
• W2471102126 hasLocation W24711021262 @default.
• W2471102126 hasOpenAccess W2471102126 @default.
• W2471102126 hasPrimaryLocation W24711021261 @default.
• W2471102126 hasRelatedWork W1964955226 @default.
• W2471102126 hasRelatedWork W1972514306 @default.
• W2471102126 hasRelatedWork W1980902712 @default.
• W2471102126 hasRelatedWork W1999017860 @default.
• W2471102126 hasRelatedWork W2014618524 @default.
• W2471102126 hasRelatedWork W2040355235 @default.
• W2471102126 hasRelatedWork W2054610559 @default.
• W2471102126 hasRelatedWork W2066413437 @default.
• W2471102126 hasRelatedWork W2332329033 @default.
• W2471102126 hasRelatedWork W2352358475 @default.
• W2471102126 hasRelatedWork W2370065623 @default.
• W2471102126 hasRelatedWork W2375005989 @default.
• W2471102126 hasRelatedWork W2393228638 @default.
• W2471102126 hasRelatedWork W2396197188 @default.
• W2471102126 hasRelatedWork W2404858575 @default.
• W2471102126 hasRelatedWork W2412398352 @default.
• W2471102126 hasRelatedWork W2427531247 @default.
• W2471102126 hasRelatedWork W2992609270 @default.
• W2471102126 hasRelatedWork W3006212451 @default.
• W2471102126 hasRelatedWork W3164476055 @default.
• W2471102126 isParatext "false" @default.
• W2471102126 isRetracted "false" @default.
• W2471102126 magId "2471102126" @default.
• W2471102126 workType "article" @default.