Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471121108> ?p ?o ?g. }
- W2471121108 endingPage "138" @default.
- W2471121108 startingPage "128" @default.
- W2471121108 abstract "Vγ9Vδ2-T cells constitute the predominant subset of γδ-T cells in human peripheral blood and have been shown to play an important role in antimicrobial and antitumor immune responses. Several efforts have been initiated to exploit these cells for cancer immunotherapy, e.g. by using phosphoantigens, adoptive cell transfer, and by a bispecific monoclonal antibody based approach. Here, we report the generation of a novel set of Vγ9Vδ2-T cell specific VHH (or nanobody). VHH have several advantages compared to conventional antibodies related to their small size, stability, ease of generating multispecific molecules and low immunogenicity. With high specificity and affinity, the anti-Vγ9Vδ2-T cell receptor VHHs are shown to be useful for FACS, MACS and immunocytochemistry. In addition, some VHH were found to specifically activate Vγ9Vδ2-T cells. Besides being of possible immunotherapeutic value, these single domain antibodies will be of great value in the further study of this important immune effector cell subset." @default.
- W2471121108 created "2016-07-22" @default.
- W2471121108 creator A5013056108 @default.
- W2471121108 creator A5013858600 @default.
- W2471121108 creator A5016627657 @default.
- W2471121108 creator A5022897881 @default.
- W2471121108 creator A5030757583 @default.
- W2471121108 creator A5048594140 @default.
- W2471121108 creator A5053105927 @default.
- W2471121108 creator A5071760135 @default.
- W2471121108 creator A5089910646 @default.
- W2471121108 creator A5090485001 @default.
- W2471121108 date "2016-08-01" @default.
- W2471121108 modified "2023-10-11" @default.
- W2471121108 title "Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications" @default.
- W2471121108 cites W1558896921 @default.
- W2471121108 cites W1976784576 @default.
- W2471121108 cites W1982611882 @default.
- W2471121108 cites W1984817631 @default.
- W2471121108 cites W1987815433 @default.
- W2471121108 cites W1992794673 @default.
- W2471121108 cites W2012400049 @default.
- W2471121108 cites W2013505681 @default.
- W2471121108 cites W2015958044 @default.
- W2471121108 cites W2024447272 @default.
- W2471121108 cites W2025827008 @default.
- W2471121108 cites W2030205190 @default.
- W2471121108 cites W2040787108 @default.
- W2471121108 cites W2043656421 @default.
- W2471121108 cites W2063096720 @default.
- W2471121108 cites W2073312795 @default.
- W2471121108 cites W2073334951 @default.
- W2471121108 cites W2085996383 @default.
- W2471121108 cites W2089069605 @default.
- W2471121108 cites W2095553811 @default.
- W2471121108 cites W2098203673 @default.
- W2471121108 cites W2103909776 @default.
- W2471121108 cites W2118828549 @default.
- W2471121108 cites W2139558439 @default.
- W2471121108 cites W2147416109 @default.
- W2471121108 cites W2147451568 @default.
- W2471121108 cites W2152488336 @default.
- W2471121108 cites W2153757228 @default.
- W2471121108 cites W2160360049 @default.
- W2471121108 cites W2165627078 @default.
- W2471121108 cites W2168848424 @default.
- W2471121108 cites W3027258573 @default.
- W2471121108 doi "https://doi.org/10.1016/j.clim.2016.06.012" @default.
- W2471121108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27373969" @default.
- W2471121108 hasPublicationYear "2016" @default.
- W2471121108 type Work @default.
- W2471121108 sameAs 2471121108 @default.
- W2471121108 citedByCount "29" @default.
- W2471121108 countsByYear W24711211082017 @default.
- W2471121108 countsByYear W24711211082018 @default.
- W2471121108 countsByYear W24711211082019 @default.
- W2471121108 countsByYear W24711211082020 @default.
- W2471121108 countsByYear W24711211082021 @default.
- W2471121108 countsByYear W24711211082022 @default.
- W2471121108 countsByYear W24711211082023 @default.
- W2471121108 crossrefType "journal-article" @default.
- W2471121108 hasAuthorship W2471121108A5013056108 @default.
- W2471121108 hasAuthorship W2471121108A5013858600 @default.
- W2471121108 hasAuthorship W2471121108A5016627657 @default.
- W2471121108 hasAuthorship W2471121108A5022897881 @default.
- W2471121108 hasAuthorship W2471121108A5030757583 @default.
- W2471121108 hasAuthorship W2471121108A5048594140 @default.
- W2471121108 hasAuthorship W2471121108A5053105927 @default.
- W2471121108 hasAuthorship W2471121108A5071760135 @default.
- W2471121108 hasAuthorship W2471121108A5089910646 @default.
- W2471121108 hasAuthorship W2471121108A5090485001 @default.
- W2471121108 hasBestOaLocation W24711211081 @default.
- W2471121108 hasConcept C1491633281 @default.
- W2471121108 hasConcept C153911025 @default.
- W2471121108 hasConcept C159654299 @default.
- W2471121108 hasConcept C19317047 @default.
- W2471121108 hasConcept C203014093 @default.
- W2471121108 hasConcept C2776090121 @default.
- W2471121108 hasConcept C2777701055 @default.
- W2471121108 hasConcept C2780868878 @default.
- W2471121108 hasConcept C51785407 @default.
- W2471121108 hasConcept C542903549 @default.
- W2471121108 hasConcept C55493867 @default.
- W2471121108 hasConcept C70721500 @default.
- W2471121108 hasConcept C86803240 @default.
- W2471121108 hasConcept C8840205 @default.
- W2471121108 hasConcept C8891405 @default.
- W2471121108 hasConcept C90375314 @default.
- W2471121108 hasConcept C95444343 @default.
- W2471121108 hasConceptScore W2471121108C1491633281 @default.
- W2471121108 hasConceptScore W2471121108C153911025 @default.
- W2471121108 hasConceptScore W2471121108C159654299 @default.
- W2471121108 hasConceptScore W2471121108C19317047 @default.
- W2471121108 hasConceptScore W2471121108C203014093 @default.
- W2471121108 hasConceptScore W2471121108C2776090121 @default.
- W2471121108 hasConceptScore W2471121108C2777701055 @default.
- W2471121108 hasConceptScore W2471121108C2780868878 @default.
- W2471121108 hasConceptScore W2471121108C51785407 @default.