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- W2471127989 endingPage "930" @default.
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- W2471127989 abstract "Pemphigus represents a group of organ specific autoimmune blistering disorders of the skin mediated by pathogenic autoantibodies with well-defined antigenic targets. While most of these diseases are sporadic, endemic forms of disease do exist. The endemic form of pemphigus foliaceus (also known as fogo selvagem, FS) exhibits epidemiological features that suggest exposure to hematophagous insect bites are a possible precipitating factor of this autoimmune disease, and provides a unique opportunity to study how environmental factors contribute to autoimmune disease development. FS patients and healthy individuals from endemic regions show an autoreactive IgM response that starts in early childhood and becomes restricted to IgG4 autoantibodies in FS patients. In searching for triggering environmental antigens, we have found that IgG4 and IgE autoantibodies from FS patients cross-react with a salivary antigen from sand flies. The presence of these cross-reactive antibodies and antibody genetic analysis confirming that these antibodies evolve from the same naïve B cells provides compelling evidence that this non-infectious environmental antigen could be the initial target of the autoantibody response in FS. Consequently, FS serves as an ideal model to study the impact of environmental antigens in the development of autoimmune disease." @default.
- W2471127989 created "2016-07-22" @default.
- W2471127989 creator A5003718702 @default.
- W2471127989 creator A5049600371 @default.
- W2471127989 creator A5050789569 @default.
- W2471127989 creator A5053518788 @default.
- W2471127989 creator A5062239388 @default.
- W2471127989 creator A5084420341 @default.
- W2471127989 date "2016-09-01" @default.
- W2471127989 modified "2023-10-14" @default.
- W2471127989 title "Non-infectious environmental antigens as a trigger for the initiation of an autoimmune skin disease" @default.
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