FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471216490> ?p ?o ?g. }

• W2471216490 endingPage "104" @default.
• W2471216490 startingPage "97" @default.
• W2471216490 abstract "It is demonstrated that patients with senile Alzheimer's type (SDAT) and alcohol related brain damage (AD) show a significant increase in ratio se-Cu/se-Zn when compared with patients with multi-infract (MID) and when compared with a matched control group. This is regarded as an indicator of zinc deficiency and relative copper toxicity in SDAT and AD, not in MID. In the same groups with SDAT and AD a high incidence of pathologically low levels of vitamin B12 in cerebrospinal fluid (CSF) was found, despite normal serum B12 levels. In MID the normal serum B12 corresponded with a normal CSF B12. This indicates abnormal function of the choroid plexus and possibly of the blood-brain barrier in SDAT and AD, not in MID. Discussed is the possibility that in a large subgroup of SDAT and AD the clinical, neurochemical and neuropathological data can be explained by the hypothesis that the combination of zinc deficiency and copper toxicity results in limbic disinhibition and defective central noradrenergic neurotransmission. The neuroendocrine effects of the limbic disinhibition and the impaired regulation of the cerebral micro-circulation by the defective noradrenergic system will result in dysfunction of the blood-brain barrier and the choroid plexus, resulting as has been demonstrated in a CSF B12 deficiency. Such an effect is strongly potentiated by a coexistent depression. Due to the reduced plasticity of the aging brain the presentation of this organic affective syndrome and/or depression is under a dementia disguise, facilitated by organic cerebral changes caused primarily by zinc deficiency and copper toxicity, secondarily by the cerebral B12 deficiency. Early recognition and adequate treatment with nutritional supplementation can possibly prevent irreversible damage in subgroups of SDAT and AD. Primary prevention by nutritional strategies can be a realistic perspective. The need for further research into this challenging hypothesis is stressed. 1. Boswijk, Dept. of Geriatric Psychiatry Psychiatric Hospital Voorburg, Vught — 5260 GB The Netherlands. Present Address: Farmers Road, Meeniyan, 3956 Victoria, Australia. Presented at Victorian State Geriatric Conference, La Trobe University, Melbourne, Australia. 1983." @default.
• W2471216490 created "2016-07-22" @default.
• W2471216490 creator A5076001820 @default.
• W2471216490 date "1984-01-01" @default.
• W2471216490 modified "2023-09-26" @default.
• W2471216490 title "Alzheimers disease/alcohol dementia: association with zinc deficiency and cerebral vitamin B12 deficiency" @default.
• W2471216490 cites W177598720 @default.
• W2471216490 cites W1785326884 @default.
• W2471216490 cites W1966518071 @default.
• W2471216490 cites W1970169677 @default.
• W2471216490 cites W1970758027 @default.
• W2471216490 cites W1971794055 @default.
• W2471216490 cites W1972096157 @default.
• W2471216490 cites W1973105173 @default.
• W2471216490 cites W1980859252 @default.
• W2471216490 cites W1981431419 @default.
• W2471216490 cites W1981436097 @default.
• W2471216490 cites W1983857744 @default.
• W2471216490 cites W1989017676 @default.
• W2471216490 cites W1992094814 @default.
• W2471216490 cites W1996870805 @default.
• W2471216490 cites W2016629760 @default.
• W2471216490 cites W2017194971 @default.
• W2471216490 cites W2020163158 @default.
• W2471216490 cites W2025701642 @default.
• W2471216490 cites W2028596519 @default.
• W2471216490 cites W2033094769 @default.
• W2471216490 cites W2037267543 @default.
• W2471216490 cites W2046397718 @default.
• W2471216490 cites W2052899121 @default.
• W2471216490 cites W2055822981 @default.
• W2471216490 cites W2063342094 @default.
• W2471216490 cites W2068440136 @default.
• W2471216490 cites W2069046227 @default.
• W2471216490 cites W2075514059 @default.
• W2471216490 cites W2091322168 @default.
• W2471216490 cites W2101865792 @default.
• W2471216490 cites W2104175936 @default.
• W2471216490 cites W2258843100 @default.
• W2471216490 cites W2261621089 @default.
• W2471216490 cites W2325851725 @default.
• W2471216490 cites W2341286085 @default.
• W2471216490 cites W2397392315 @default.
• W2471216490 cites W2410757758 @default.
• W2471216490 cites W2415691956 @default.
• W2471216490 cites W2419076515 @default.
• W2471216490 cites W2443540937 @default.
• W2471216490 cites W2472425414 @default.
• W2471216490 cites W2889348848 @default.
• W2471216490 cites W3021255011 @default.
• W2471216490 cites W377358013 @default.
• W2471216490 cites W587409523 @default.
• W2471216490 cites W616955955 @default.
• W2471216490 cites W85949484 @default.
• W2471216490 cites W17788350 @default.
• W2471216490 cites W2244669784 @default.
• W2471216490 hasPublicationYear "1984" @default.
• W2471216490 type Work @default.
• W2471216490 sameAs 2471216490 @default.
• W2471216490 citedByCount "5" @default.
• W2471216490 crossrefType "journal-article" @default.
• W2471216490 hasAuthorship W2471216490A5076001820 @default.
• W2471216490 hasConcept C126322002 @default.
• W2471216490 hasConcept C134018914 @default.
• W2471216490 hasConcept C170493617 @default.
• W2471216490 hasConcept C187714386 @default.
• W2471216490 hasConcept C2775864247 @default.
• W2471216490 hasConcept C2776538271 @default.
• W2471216490 hasConcept C2777952318 @default.
• W2471216490 hasConcept C2779134260 @default.
• W2471216490 hasConcept C2779483572 @default.
• W2471216490 hasConcept C2779651940 @default.
• W2471216490 hasConcept C2779750884 @default.
• W2471216490 hasConcept C502032728 @default.
• W2471216490 hasConcept C529278444 @default.
• W2471216490 hasConcept C541082541 @default.
• W2471216490 hasConcept C71924100 @default.
• W2471216490 hasConceptScore W2471216490C126322002 @default.
• W2471216490 hasConceptScore W2471216490C134018914 @default.
• W2471216490 hasConceptScore W2471216490C170493617 @default.
• W2471216490 hasConceptScore W2471216490C187714386 @default.
• W2471216490 hasConceptScore W2471216490C2775864247 @default.
• W2471216490 hasConceptScore W2471216490C2776538271 @default.
• W2471216490 hasConceptScore W2471216490C2777952318 @default.
• W2471216490 hasConceptScore W2471216490C2779134260 @default.
• W2471216490 hasConceptScore W2471216490C2779483572 @default.
• W2471216490 hasConceptScore W2471216490C2779651940 @default.
• W2471216490 hasConceptScore W2471216490C2779750884 @default.
• W2471216490 hasConceptScore W2471216490C502032728 @default.
• W2471216490 hasConceptScore W2471216490C529278444 @default.
• W2471216490 hasConceptScore W2471216490C541082541 @default.
• W2471216490 hasConceptScore W2471216490C71924100 @default.
• W2471216490 hasIssue "2" @default.
• W2471216490 hasLocation W24712164901 @default.
• W2471216490 hasOpenAccess W2471216490 @default.
• W2471216490 hasPrimaryLocation W24712164901 @default.
• W2471216490 hasRelatedWork W128775836 @default.
• W2471216490 hasRelatedWork W1894098853 @default.

• next