Matches in SemOpenAlex for { <https://semopenalex.org/work/W2471256249> ?p ?o ?g. }
- W2471256249 endingPage "71" @default.
- W2471256249 startingPage "62" @default.
- W2471256249 abstract "Acute lymphoblastic leukemia (ALL) is a hematologic malignancy that predominantly occurs in children between 2 and 10 years of age. L-asparaginase is an integral component of treatment for patients with ALL and since its introduction into pediatric treatment protocols in the 1960s, survival rates in children have progressively risen to nearly 90%. Outcomes for adolescent and young adult (AYA) patients, aged 15-39 years and diagnosed with ALL, have historically been less favorable. However, recent reports suggest substantially increased survival in AYA patients treated on pediatric-inspired protocols that include a greater cumulative dose of asparaginase. All currently available asparaginases share the same mechanism of action - the deamination and depletion of serum asparagine levels - yet each displays a markedly different pharmacokinetic profile. Pegylated asparaginase derived from the bacterium Escherichia coli is used as first-line therapy; however, up to 30% of patients develop a treatment-limiting hypersensitivity reaction. Patients who experience a hypersensitivity reaction to an E. coli-derived asparaginase can continue treatment with Erwinia chrysanthemi asparaginase. Erwinia asparaginase is immunologically distinct from E. coli-derived asparaginases and exhibits no cross-reactivity. Studies have shown that with adequate dosing, therapeutic levels of Erwinia asparaginase activity can be achieved, and patients switched to Erwinia asparaginase due to hypersensitivity can obtain outcomes similar to patients who do not experience a hypersensitivity reaction. Therapeutic drug monitoring may be required to ensure that therapeutic levels of asparaginase activity are maintained." @default.
- W2471256249 created "2016-07-22" @default.
- W2471256249 creator A5027519806 @default.
- W2471256249 creator A5034600739 @default.
- W2471256249 creator A5053519615 @default.
- W2471256249 date "2016-06-01" @default.
- W2471256249 modified "2023-10-11" @default.
- W2471256249 title "L-asparaginase in the treatment of patients with acute lymphoblastic leukemia" @default.
- W2471256249 cites W142226155 @default.
- W2471256249 cites W1506630672 @default.
- W2471256249 cites W1510505199 @default.
- W2471256249 cites W1515224725 @default.
- W2471256249 cites W1528693378 @default.
- W2471256249 cites W1536189216 @default.
- W2471256249 cites W1595924202 @default.
- W2471256249 cites W1821438013 @default.
- W2471256249 cites W1838641826 @default.
- W2471256249 cites W1862517694 @default.
- W2471256249 cites W1887863677 @default.
- W2471256249 cites W1896861650 @default.
- W2471256249 cites W1920035725 @default.
- W2471256249 cites W1930895125 @default.
- W2471256249 cites W1940732706 @default.
- W2471256249 cites W1944430150 @default.
- W2471256249 cites W1953387859 @default.
- W2471256249 cites W1965542498 @default.
- W2471256249 cites W1965769627 @default.
- W2471256249 cites W1966763079 @default.
- W2471256249 cites W1970593462 @default.
- W2471256249 cites W1977546984 @default.
- W2471256249 cites W1980035039 @default.
- W2471256249 cites W1984258977 @default.
- W2471256249 cites W1989771063 @default.
- W2471256249 cites W1992750424 @default.
- W2471256249 cites W1995007817 @default.
- W2471256249 cites W1995473821 @default.
- W2471256249 cites W2004681740 @default.
- W2471256249 cites W2005688611 @default.
- W2471256249 cites W2005733409 @default.
- W2471256249 cites W2005753411 @default.
- W2471256249 cites W2007102329 @default.
- W2471256249 cites W2010002712 @default.
- W2471256249 cites W2010729137 @default.
- W2471256249 cites W20112094 @default.
- W2471256249 cites W2011332592 @default.
- W2471256249 cites W2012808596 @default.
- W2471256249 cites W2016822528 @default.
- W2471256249 cites W2016833582 @default.
- W2471256249 cites W2017265604 @default.
- W2471256249 cites W2018374431 @default.
- W2471256249 cites W2021422854 @default.
- W2471256249 cites W2024777863 @default.
- W2471256249 cites W2024893955 @default.
- W2471256249 cites W2028579560 @default.
- W2471256249 cites W2032519529 @default.
- W2471256249 cites W2034115389 @default.
- W2471256249 cites W2035309334 @default.
- W2471256249 cites W2040730344 @default.
- W2471256249 cites W2043587224 @default.
- W2471256249 cites W2047657755 @default.
- W2471256249 cites W2049552282 @default.
- W2471256249 cites W2052739233 @default.
- W2471256249 cites W2052816946 @default.
- W2471256249 cites W2052925094 @default.
- W2471256249 cites W2053852136 @default.
- W2471256249 cites W2056667876 @default.
- W2471256249 cites W2058713665 @default.
- W2471256249 cites W2060440673 @default.
- W2471256249 cites W2060876075 @default.
- W2471256249 cites W2066868518 @default.
- W2471256249 cites W2067585473 @default.
- W2471256249 cites W2068619849 @default.
- W2471256249 cites W2074521332 @default.
- W2471256249 cites W2080828049 @default.
- W2471256249 cites W2084089666 @default.
- W2471256249 cites W2084612827 @default.
- W2471256249 cites W2086930991 @default.
- W2471256249 cites W2090181358 @default.
- W2471256249 cites W2092979043 @default.
- W2471256249 cites W2096489857 @default.
- W2471256249 cites W2097682287 @default.
- W2471256249 cites W2103347449 @default.
- W2471256249 cites W2104165703 @default.
- W2471256249 cites W2105435030 @default.
- W2471256249 cites W2105746514 @default.
- W2471256249 cites W2106275447 @default.
- W2471256249 cites W2108008366 @default.
- W2471256249 cites W2113477288 @default.
- W2471256249 cites W2113512182 @default.
- W2471256249 cites W2114064238 @default.
- W2471256249 cites W2117623554 @default.
- W2471256249 cites W2117823975 @default.
- W2471256249 cites W2127153931 @default.
- W2471256249 cites W2134118606 @default.
- W2471256249 cites W2137365058 @default.
- W2471256249 cites W2140819149 @default.
- W2471256249 cites W2145662640 @default.
- W2471256249 cites W2146375276 @default.