FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W247127784> ?p ?o ?g. }

• W247127784 endingPage "4433" @default.
• W247127784 startingPage "4427" @default.
• W247127784 abstract "Abstract Three chimpanzees experimentally infected with human immunodeficiency virus (HIV) developed significant chronic thrombocytopenia after 5, 4, and 2 years, with peripheral platelet counts averaging 64 ± 19 × 103/μL (P = .004 compared with 228 ± 92 × 103/μL in 44 normal control animals), mean platelet volumes of 11.2 ± 1.8 fL (P &gt; .5 compared with 10.9 ± 0.7 fL in normal controls), endogenous thrombopoietin (TPO) levels of 926 ± 364 pg/mL (P &lt; .001 compared with 324 ± 256 pg/mL in normal controls), uniformly elevated platelet anti-glycoprotein (GP) IIIa49-66 antibodies, and corresponding viral loads of 534, 260, and 15 × 103 RNA viral copies/mL. Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) was administered subcutaneously (25 μg/kg twice weekly for 3 doses) to determine the effects of stimulating platelet production on peripheral platelet concentrations in this cohort of thrombocytopenic HIV-infected chimpanzees. PEG-rHuMGDF therapy increased (1) peripheral platelet counts 10-fold (from 64 ± 19 to 599 ± 260 × 103 platelets/μL;P = .02); (2) marrow megakaryocyte numbers 30-fold (from 11.7 ± 6.5 × 106/kg to 353 ± 255 × 106/kg;P = .04); (3) marrow megakaryocyte progenitor cells fourfold (from a mean of 3.6 ± 0.6 to 14.1 × 103 CFU-Meg/1,000 CD34+ marrow cells); and (4) serum levels of Mpl ligand from 926 ± 364 pg/mL (endogenous TPO) to predosing trough levels of 1,840 ± 353 pg/mL PEG-rHuMGDF (P = .02). The peripheral neutrophil counts were also transiently increased from 5.2 ± 2.6 × 103/μL to 9.9 ± 5.0 × 103/μL (P= .01), but neither the erythrocyte counts nor the reticulocyte counts were altered significantly (P &gt; .1). The serum levels of antiplatelet GPIIIa49-66 antibodies exhibited reciprocal reductions during periods of thrombocytosis (P &lt; .07). PEG-rHuMGDF therapy did not increase viral loads significantly (395, 189, and 53 × 103 RNA viral copies/mL; P &gt; .5 compared with baseline values). The striking increase in peripheral platelet counts produced by PEG-rHuMGDF therapy implies that thrombocytopenia in HIV-infected chimpanzees is attributable to insufficient compensatory expansion in platelet production resulting from HIV-impaired delivery of platelets despite stimulated megakaryocytopoiesis. These data suggest that PEG-rHuMGDF therapy may similarly correct peripheral platelet counts in thrombocytopenic HIV-infected patients." @default.
• W247127784 created "2016-06-24" @default.
• W247127784 creator A5003967366 @default.
• W247127784 creator A5011386306 @default.
• W247127784 creator A5026353791 @default.
• W247127784 creator A5047037554 @default.
• W247127784 creator A5065379380 @default.
• W247127784 creator A5074077148 @default.
• W247127784 creator A5081761664 @default.
• W247127784 creator A5084568262 @default.
• W247127784 creator A5087925525 @default.
• W247127784 date "1998-06-15" @default.
• W247127784 modified "2023-09-30" @default.
• W247127784 title "Treatment of Thrombocytopenia in Chimpanzees Infected With Human Immunodeficiency Virus by Pegylated Recombinant Human Megakaryocyte Growth and Development Factor" @default.
• W247127784 cites W111332543 @default.
• W247127784 cites W1519535724 @default.
• W247127784 cites W1520666812 @default.
• W247127784 cites W1534976847 @default.
• W247127784 cites W1578509365 @default.
• W247127784 cites W1580484836 @default.
• W247127784 cites W1894438159 @default.
• W247127784 cites W1965228684 @default.
• W247127784 cites W1970815539 @default.
• W247127784 cites W1972847637 @default.
• W247127784 cites W198401084 @default.
• W247127784 cites W2002415786 @default.
• W247127784 cites W2009966623 @default.
• W247127784 cites W2014369252 @default.
• W247127784 cites W2022854476 @default.
• W247127784 cites W2033248764 @default.
• W247127784 cites W2042999497 @default.
• W247127784 cites W2045321764 @default.
• W247127784 cites W2045403351 @default.
• W247127784 cites W2057015685 @default.
• W247127784 cites W2059052465 @default.
• W247127784 cites W2059770652 @default.
• W247127784 cites W2061382718 @default.
• W247127784 cites W2078123555 @default.
• W247127784 cites W2078800192 @default.
• W247127784 cites W2090718632 @default.
• W247127784 cites W2094562745 @default.
• W247127784 cites W2104470055 @default.
• W247127784 cites W2125354973 @default.
• W247127784 cites W2143531841 @default.
• W247127784 cites W2145376670 @default.
• W247127784 cites W2152303123 @default.
• W247127784 cites W2152700768 @default.
• W247127784 cites W2166229810 @default.
• W247127784 cites W2246880911 @default.
• W247127784 cites W2312499014 @default.
• W247127784 cites W2317912629 @default.
• W247127784 cites W2353981192 @default.
• W247127784 cites W2412664674 @default.
• W247127784 cites W2418305903 @default.
• W247127784 cites W270059477 @default.
• W247127784 cites W291798906 @default.
• W247127784 cites W36901207 @default.
• W247127784 cites W4229510792 @default.
• W247127784 cites W4251851844 @default.
• W247127784 doi "https://doi.org/10.1182/blood.v91.12.4427" @default.
• W247127784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9616135" @default.
• W247127784 hasPublicationYear "1998" @default.
• W247127784 type Work @default.
• W247127784 sameAs 247127784 @default.
• W247127784 citedByCount "39" @default.
• W247127784 countsByYear W2471277842013 @default.
• W247127784 countsByYear W2471277842015 @default.
• W247127784 countsByYear W2471277842018 @default.
• W247127784 crossrefType "journal-article" @default.
• W247127784 hasAuthorship W247127784A5003967366 @default.
• W247127784 hasAuthorship W247127784A5011386306 @default.
• W247127784 hasAuthorship W247127784A5026353791 @default.
• W247127784 hasAuthorship W247127784A5047037554 @default.
• W247127784 hasAuthorship W247127784A5065379380 @default.
• W247127784 hasAuthorship W247127784A5074077148 @default.
• W247127784 hasAuthorship W247127784A5081761664 @default.
• W247127784 hasAuthorship W247127784A5084568262 @default.
• W247127784 hasAuthorship W247127784A5087925525 @default.
• W247127784 hasConcept C109159458 @default.
• W247127784 hasConcept C126322002 @default.
• W247127784 hasConcept C134018914 @default.
• W247127784 hasConcept C203014093 @default.
• W247127784 hasConcept C2776958478 @default.
• W247127784 hasConcept C2777863708 @default.
• W247127784 hasConcept C2779705218 @default.
• W247127784 hasConcept C28328180 @default.
• W247127784 hasConcept C54355233 @default.
• W247127784 hasConcept C71924100 @default.
• W247127784 hasConcept C86803240 @default.
• W247127784 hasConcept C89560881 @default.
• W247127784 hasConceptScore W247127784C109159458 @default.
• W247127784 hasConceptScore W247127784C126322002 @default.
• W247127784 hasConceptScore W247127784C134018914 @default.
• W247127784 hasConceptScore W247127784C203014093 @default.
• W247127784 hasConceptScore W247127784C2776958478 @default.
• W247127784 hasConceptScore W247127784C2777863708 @default.
• W247127784 hasConceptScore W247127784C2779705218 @default.
• W247127784 hasConceptScore W247127784C28328180 @default.

• next